MicroRNAs in Septic Acute Kidney Injury

Overview

Journal Burns Trauma

Publisher Oxford University Press

Date 2023 Mar 24

PMID 36959845

Authors

Bo Wang

Jun Xu

Ping Fu

Liang Ma

Affiliations

Soon will be listed here.

Abstract

Sepsis is a potentially fatal complication of burns and trauma that can cause acute kidney injury (AKI) with substantial morbidity and mortality, but this disease is poorly understood. Despite medical advances, effective therapeutic regimens for septic AKI remain uncommon. MicroRNAs (miRNAs) are endogenous non-coding RNAs that influence the translation of target messenger RNAs in a variety of biological processes. Emerging evidence has shown that miRNAs are intimately associated with septic AKI. The goal of this review was to summarize recent advances in the profound understanding of the functional role of miRNAs in septic AKI, as well as to provide new insights into miRNAs as feasible biomarkers and therapeutic targets for septic AKI.

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