Bone, Cognitive, and Anthropometric Profiles and Their Relation to Fracture Sites in Fallers: a Cross-sectional Study

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2023 Mar 24

PMID 36959306

Authors

Maelle Baillet

Remy Morello

Olivier Vittecoq

Chantal Chavoix

Christian Marcelli

Affiliations

Soon will be listed here.

Abstract

Purpose: Risk factors involved in the different osteoporotic fracture locations are not well-known. The aim of this study was to identify the differences in bone, cognitive, and anthropometric characteristics between different fracture sites, and to determine whether the site of a fall-related fracture is related to a specific profile.

Methods: One hundred six women aged 55 years and older with a recent fall-related fracture of the hip (n = 30), humerus (n = 28), wrist (n = 32), or ankle (n = 16) were included. Bone, cognitive, and anthropometric characteristics were first compared among the four fracture site groups. Then, a principal component analysis (PCA) was performed and a comparison was made between the four profiles identified by the first two PCA components.

Results: The four fracture site groups differed significantly in their education level, bone mineral density (BMD), body mass index (BMI), fear of falling, and number of errors in the Trail Making Test B, an executive function test. Each of the four fracture sites was found in each four PCA profiles, albeit with a different distribution. The profiles differed mainly by bone, cognitive, and anthropometric characteristics, but also by fear of falling.

Conclusions: The fall-related fracture sites differ significantly in anthropometric and bone parameters, in fear of falling and in cognitive abilities. There is not one typical bone, cognitive, and anthropometric profile characterising a particular fall-related site, but rather several possible profiles for a given site. This suggests that the fracture site depends on a combination of several characteristics of the patient.

Citing Articles

Involvement of cognitive abilities in the occurrence of fractures in fallers aged 55 years or older: a cross-sectional study.

Attoh-Mensah E, Pothier K, Loggia G, Morello R, Chavoix C, Marcelli C Aging Clin Exp Res. 2024; 36(1):180.

PMID: 39212862 PMC: 11364792. DOI: 10.1007/s40520-024-02830-7.

The impact of bone mineral density on the risk of falling: evidence from genetic correlation and Mendelian randomization analysis.

Mao R, Peng L, Zhang Y, Li L, Ren Y Endocrine. 2024; 86(1):380-390.

PMID: 38851644 DOI: 10.1007/s12020-024-03904-2.

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