Increases the Potential of Breast Cancer by Reducing the Expression of the P53 Protein

Introduction: Breast cancer is considered the most frequent type of cancer in women with high mortality worldwide, and most importantly, it is the second most common cancer. However, some breast cancer-related risk factors remain unknown. So, the current study was designed to evaluate the effect of on the biomarkers correlated with proliferation, apoptosis, inflammation, and angiogenesis in 4T1 tumor-bearing mice infected with for the first time.

Methods: Mice were categorized into four groups: A) control, B) treated with 4T1+ , C) treated with , and D) treated with 4T1. The expression of Ki-67 and P53 was then evaluated by using the immunohistochemical technique. In addition, the levels of transforming growth factor-β, Interferon gamma-γ, Interleukin 10, tumor necrosis factor-α and vascular endothelial growth factor as well as anti- IgG were determined using the enzyme-linked immunosorbent assay method.

Results: The expression of Ki-67 was significantly increased in the 4T1+ group than control and groups ( < 0.001 and < 0.001, respectively). Moreover, a significant decrease in P53 was found in the 4T1+ group than in the control and groups ( < 0.001 and < 0.001, respectively). Also, the 4T1+ group significantly reduced the expression of P53 more than 4T1 tumor-bearing mice ( = 0.005). In addition, the 4T1+ Toxocara canis group had an increasing tumor necrosis factor-α and vascular endothelial growth factor than controls ( = 0.004 and = 0.002, respectively). Furthermore, a significant reduction in Interleukin 10 was found in the 4T1+ group than in the control group ( = 0.004).

Conclusion: Our findings showed that could probably increase the potential of breast cancer by reducing P53 in 4T1 tumor-bearing mice infected with more than other groups.