Monitoring Mouse Brain Perfusion with Hybrid Magnetic Resonance Optoacoustic Tomography

Overview

Journal Biomed Opt Express

Specialty Radiology

Date 2023 Mar 23

PMID 36950237

Authors

Wuwei Ren

Xose Luis Dean-Ben

Zhiva Skachokova

Mark-Aurel Augath

Ruiqing Ni

Zhenyue Chen

Daniel Razansky

Affiliations

Soon will be listed here.

Abstract

Progress in brain research critically depends on the development of next-generation multi-modal imaging tools capable of capturing transient functional events and multiplexed contrasts noninvasively and concurrently, thus enabling a holistic view of dynamic events . Here we report on a hybrid magnetic resonance and optoacoustic tomography (MROT) system for murine brain imaging, which incorporates an MR-compatible spherical matrix array transducer and fiber-based light illumination into a 9.4 T small animal scanner. An optimized radiofrequency coil has further been devised for whole-brain interrogation. System's utility is showcased by acquiring complementary angiographic and soft tissue anatomical contrast along with simultaneous dual-modality visualization of contrast agent dynamics .

Citing Articles

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Bauer A, Gibson E, Wang H, Srinivasan V Biomed Opt Express. 2024; 15(4):2110-2113.

PMID: 38633102 PMC: 11019680. DOI: 10.1364/BOE.517678.

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