Relationship Between HuR and Tumor Drug Resistance

Overview

Journal Clin Transl Oncol

Specialty Oncology

Date 2023 Mar 22

PMID 36947360

Authors

Qiancheng Ma

Qiliang Lu

Xiangxiang Lei

Jie Zhao

Wen Sun

Dongsheng Huang

Qing Zhu

Qiuran Xu

Affiliations

Soon will be listed here.

Abstract

Human resistance protein R (HuR), also known as embryonic lethal abnormal visual-like protein (ELAVL1), is an RNA-binding protein widely expressed in vivo that affects the mRNA stability of targeted and is involved in post-transcriptional regulation. Recent studies have shown that HuR is aberrantly expressed in different human cancers and is an essential factor in poor clinical prognosis. The role of HuR in numerous tumors suggests that it could be a new target for tumor therapy and as a marker for efficacy and prognostic assessment. This review focuses on the relationship between HuR and drug resistance in different tumors and briefly describes the structure, function, and inhibitors of HuR. We summarize the mechanisms by which HuR causes tumor resistance and the molecular targets affected.

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