Glia-neuron Coupling Via a Bipartite Sialylation Pathway Promotes Neural Transmission and Stress Tolerance in

Overview

Journal Elife

Specialty Biology

Date 2023 Mar 22

PMID 36946697

Authors

Hilary Scott

Boris Novikov

Berrak Ugur

Brooke Allen

Ilya Mertsalov

Pedro Monagas-Valentin

Melissa Koff

Sarah Baas Robinson

Kazuhiro Aoki

Raisa Veizaj

Dirk J Lefeber

Michael Tiemeyer

Hugo Bellen

Vladislav Panin

Affiliations

Soon will be listed here.

Abstract

Modification by sialylated glycans can affect protein functions, underlying mechanisms that control animal development and physiology. Sialylation relies on a dedicated pathway involving evolutionarily conserved enzymes, including CMP-sialic acid synthetase (CSAS) and sialyltransferase (SiaT) that mediate the activation of sialic acid and its transfer onto glycan termini, respectively. In , and genes function in the nervous system, affecting neural transmission and excitability. We found that these genes function in different cells: the function of is restricted to glia, while functions in neurons. This partition of the sialylation pathway allows for regulation of neural functions via a glia-mediated control of neural sialylation. The sialylation genes were shown to be required for tolerance to heat and oxidative stress and for maintenance of the normal level of voltage-gated sodium channels. Our results uncovered a unique bipartite sialylation pathway that mediates glia-neuron coupling and regulates neural excitability and stress tolerance.

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