Prevalence of Lewy Pathology in Essential Tremor is Twice As High As Expected: A Plausible Explanation for the Enhanced Risk for Parkinson Disease Seen in Essential Tremor Cases

Overview

Journal J Neuropathol Exp Neurol

Publisher Oxford University Press

Specialties Neurology
Pathology

Date 2023 Mar 21

PMID 36943259

Authors

Elan D Louis

Phyllis L Faust

Affiliations

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Essential tremor with tau pathology features seeds indistinguishable in conformation from Alzheimer's disease and primary age-related tauopathy.

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Six Myths and Misconceptions about Essential Tremor.

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References

Tan E, Lee S, S F, Lum S . Evidence of increased odds of essential tremor in Parkinson's disease. Mov Disord. 2008; 23(7):993-997. DOI: 10.1002/mds.22005. View

Costello S, Bordelon Y, Bronstein J, Ritz B . Familial associations of Alzheimer disease and essential tremor with Parkinson disease. Eur J Neurol. 2010; 17(6):871-8. PMC: 2895681. DOI: 10.1111/j.1468-1331.2010.02974.x. View

LaRoia H, Louis E . Association between essential tremor and other neurodegenerative diseases: what is the epidemiological evidence?. Neuroepidemiology. 2011; 37(1):1-10. PMC: 3142098. DOI: 10.1159/000328866. View

Spanaki C, Plaitakis A . Essential tremor in Parkinson's disease kindreds from a population of similar genetic background. Mov Disord. 2009; 24(11):1662-8. DOI: 10.1002/mds.22655. View

Benito-Leon J, Louis E, Bermejo-Pareja F . Risk of incident Parkinson's disease and parkinsonism in essential tremor: a population based study. J Neurol Neurosurg Psychiatry. 2009; 80(4):423-5. DOI: 10.1136/jnnp.2008.147223. View

Choe M, Cortes E, Vonsattel J, Kuo S, Faust P, Louis E . Purkinje cell loss in essential tremor: Random sampling quantification and nearest neighbor analysis. Mov Disord. 2016; 31(3):393-401. PMC: 4783222. DOI: 10.1002/mds.26490. View

Dugger B, Hentz J, Adler C, Sabbagh M, Shill H, Jacobson S . Clinicopathological outcomes of prospectively followed normal elderly brain bank volunteers. J Neuropathol Exp Neurol. 2014; 73(3):244-52. PMC: 4066814. DOI: 10.1097/NEN.0000000000000046. View

Tarakad A, Jankovic J . Essential Tremor and Parkinson's Disease: Exploring the Relationship. Tremor Other Hyperkinet Mov (N Y). 2019; 8:589. PMC: 6329774. DOI: 10.7916/D8MD0GVR. View

Thenganatt M, Jankovic J . The relationship between essential tremor and Parkinson's disease. Parkinsonism Relat Disord. 2015; 22 Suppl 1:S162-5. DOI: 10.1016/j.parkreldis.2015.09.032. View

10.

Louis E, Faust P . Purkinje cell loss in essential tremor. Mov Disord. 2014; 29(10):1329-30. PMC: 4162819. DOI: 10.1002/mds.25965. View

11.

Louis E, Faust P . Essential tremor pathology: neurodegeneration and reorganization of neuronal connections. Nat Rev Neurol. 2020; 16(2):69-83. DOI: 10.1038/s41582-019-0302-1. View

12.

Louis E, Iglesias-Hernandez D, Hernandez N, Flowers X, Kuo S, Vonsattel J . Characterizing Lewy Pathology in 231 Essential Tremor Brains From the Essential Tremor Centralized Brain Repository. J Neuropathol Exp Neurol. 2022; 81(10):796-806. PMC: 9487643. DOI: 10.1093/jnen/nlac068. View