María Teresa Miras Portugal: a Pioneer in the Study of Purinoceptors in Chromaffin Cells

Overview

Journal Purinergic Signal

Publisher Springer

Date 2023 Mar 21

PMID 36941507

Authors

Antonio R Artalejo

Marina Arribas-Blazquez

Maria Victoria Barahona

Celia Llorente-Saez

Luis Alcides Olivos-Ore

Affiliations

Soon will be listed here.

Abstract

María Teresa Miras Portugal devoted most of her scientific life to the study of purinergic signalling. In an important part of her work, she used a model system: the chromaffin cells of the adrenal medulla. It was in these cells that she identified diadenosine polyphosphates, from which she proceeded to the study of adrenomedullary purinome: nucleotide synthesis and degradation, adenosine transport, nucleotide uptake into chromaffin granules, exocytotic release of nucleotides and autocrine regulation of chromaffin cell function via purinoceptors. This short review will focus on the current state of knowledge of the purinoceptors of adrenal chromaffin cells, a subject to which María Teresa made seminal contributions and which she continued to study until the end of her scientific life.

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