National Cancer Institute (NCI) Program for Natural Product Discovery: Exploring NCI-60 Screening Data of Natural Product Samples with Artificial Neural Networks

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2023 Mar 20

PMID 36936303

Authors

Jason R Evans

Rhone K Akee

Shaurya Chanana

Grant D McConachie

Christopher C Thornburg

Tanja Grkovic

Barry R OKeefe

Affiliations

Soon will be listed here.

Abstract

National Cancer Institute (NCI) Program for Natural Product Discovery is a new initiative aimed at creating new technologies for natural product-based drug discovery. Here, we present the development of a neural network-based bioinformatics platform for visualization and analysis of natural product high-throughput screening data using the NCI's 60 human tumor cell anticancer drug screen. We demonstrate how the tool enables visualization of similar patterns of response that can be parsed both chemically and taxonomically, grouping NCI-60 biological profiles in one easy-to-use bioinformatics interface.

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