Influence of Methyl Donor Nutrients As Epigenetic Regulators in Colorectal Cancer: A Systematic Review of Observational Studies

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2023 Mar 17

PMID 36926668

Authors

Lourdes Pilar Chavez-Hidalgo

Silvia Martin-Fernandez-de-Labastida

Marian M de Pancorbo

Marta Arroyo-Izaga

Affiliations

Soon will be listed here.

Abstract

Background: Dietary methyl donors might influence DNA methylation during carcinogenesis of colorectal cancer (CRC). However, whether the influence of methyl donor intake is modified by polymorphisms in such epigenetic regulators is still unclear.

Aim: To improve the current understanding of the molecular basis of CRC

Methods: A literature search in the Medline database, (https:// www.referencecitationanalysis.com/), and manual reference screening were performed to identify observational studies published from inception to May 2022.

Results: A total of fourteen case-control studies and five cohort studies were identified. These studies included information on dietary methyl donors, dietary components that potentially modulate the bioavailability of methyl groups, genetic variants of methyl metabolizing enzymes, and/or markers of CpG island methylator phenotype and/or microsatellite instability, and their possible interactions on CRC risk.

Conclusion: Several studies have suggested interactions between methylenetetrahydrofolate reductase polymorphisms, methyl donor nutrients (such as folate) and alcohol on CRC risk. Moreover, vitamin B, niacin, and alcohol may affect CRC risk through not only genetic but also epigenetic regulation. Identification of specific mechanisms in these interactions associated with CRC may assist in developing targeted prevention strategies for individuals at the highest risk of developing CRC.

Citing Articles

Recommendations for articles and reviews in colorectal cancer-related research at the year-end of 2023.

Luan W, Lin H, Miao Y World J Gastroenterol. 2024; 30(30):3548-3553.

PMID: 39193570 PMC: 11346154. DOI: 10.3748/wjg.v30.i30.3548.

Editor-in-Chief articles of choice and comments at the year-end of 2023.

Tarnawski A World J Gastroenterol. 2024; 30(1):1-8.

PMID: 38293322 PMC: 10823905. DOI: 10.3748/wjg.v30.i1.1.

The Nutriepigenome.

Mirisola M Genes (Basel). 2023; 14(11).

PMID: 38002940 PMC: 10671240. DOI: 10.3390/genes14111997.

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