TRNA Modifications and Modifying Enzymes in Disease, the Potential Therapeutic Targets

Overview

Journal Int J Biol Sci

Specialty Biology

Date 2023 Mar 16

PMID 36923941

Authors

Weifang Cui

Deze Zhao

Junjie Jiang

Faqing Tang

Chunfang Zhang

Chaojun Duan

Affiliations

Soon will be listed here.

Abstract

tRNA is one of the most conserved and abundant RNA species, which plays a key role during protein translation. tRNA molecules are post-transcriptionally modified by tRNA modifying enzymes. Since high-throughput sequencing technology has developed rapidly, tRNA modification types have been discovered in many research fields. In tRNA, numerous types of tRNA modifications and modifying enzymes have been implicated in biological functions and human diseases. In our review, we talk about the relevant biological functions of tRNA modifications, including tRNA stability, protein translation, cell cycle, oxidative stress, and immunity. We also explore how tRNA modifications contribute to the progression of human diseases. Based on previous studies, we discuss some emerging techniques for assessing tRNA modifications to aid in discovering different types of tRNA modifications.

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