S100A8/S100A9 Promote Progression of Multiple Myeloma Via Expansion of Megakaryocytes

Overview

Journal Cancer Res Commun

Specialty Oncology

Date 2023 Mar 16

PMID 36923707

Authors

Cindy Lin

Laura Garcia-Gerique

Erin E Bonner

Jerome Mastio

Matthew Rosenwasser

Zachary Cruz

Michael Lawler

Luca Bernabei

Kar Muthumani

Qin Liu

Mortimer Poncz

Thomas Vogl

Marie Torngren

Helena Eriksson

Dan T Vogl

Dmitry I Gabrilovich

Yulia Nefedova

Affiliations

Soon will be listed here.

Abstract

Significance: We identified a novel mechanism by which myeloid cells promote myeloma progression independently of the adaptive immune system. Specifically, we discovered a novel role of S100A8/S100A9, the most abundant proteins produced by neutrophils and monocytes, in regulation of myeloma progression via promotion of the megakaryocyte expansion and angiogenesis. Tasquinimod, an inhibitor of S100A9, has potent antimyeloma effects as a single agent and in combination with lenalidomide and with proteasome inhibitors.

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