Brain Neural Progenitors Are New Predictive Biomarkers for Breast Cancer Hormonotherapy

Overview

Journal Cancer Res Commun

Specialty Oncology

Date 2023 Mar 16

PMID 36923306

Authors

Agnes Basseville

Chiara Cordier

Fadoua Ben Azzouz

Wilfried Gouraud

Hamza Lasla

Fabien Panloup

Mario Campone

Pascal Jezequel

Affiliations

Soon will be listed here.

Abstract

Significance: The development of personalized and precision medicine is the future of cancer therapy. With only two gene expression signatures approved by FDA for breast cancer, we are in need of new ones that can reliably stratify patients for optimal treatment. This study provides two hormonotherapy-predictive and prognostic signatures that are related to nervous system in TME. It highlights tumor neuronal components as potential new targets for breast cancer therapy.

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Gene Signature Associated with Nervous System in an Experimental Radiation- and Estrogen-Induced Breast Cancer Model.

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