Epimedin C Protects Dexamethasone-induced Osteoblasts Through NRF1/RhoA Pathway

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2023 Mar 15

PMID 36920182

Authors

Mi Huang

Lei Yu

Ying Wang

Chunlin Yang

Affiliations

Soon will be listed here.

Abstract

Osteoporosis (OP) is a metabolic bone disease that leads to decrease of bone strength and increase bone brittle and fracture. Dexamethasone (DXMS) usage is a common risk factor of OP. In present study, we found that the Epimedin C protect the DXMS-induced OP, Ras Homolog Family Member A transforming protein (RhoA) was increased in osteoblasts (OBs) and OP models. We further revealed that Nrf1 is a transcription factor that responds to Epimedin C and DXMS in modulating RhoA promoter. The results collectively demonstrate that Epimedin C functions as a positive modifier of RhoA via alteration of Nrf1 transcriptional activity on RhoA promoter, thereby, protecting OBs against OP. Our work is the first study identifying the Epimedin C function in balancing the OBs in OP model via Nrf1-RhoA.

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