Crimean-Congo Haemorrhagic Fever Virus

Overview

Journal Nat Rev Microbiol

Specialties Infectious Diseases
Microbiology

Date 2023 Mar 15

PMID 36918725

Authors

David W Hawman

Heinz Feldmann

Affiliations

Soon will be listed here.

Abstract

Crimean-Congo haemorrhagic fever (CCHF) is a severe tick-borne illness with a wide geographical distribution and case fatality rates of 30% or higher. Caused by infection with the CCHF virus (CCHFV), cases are reported throughout Africa, the Middle East, Asia and southern and eastern Europe. The expanding range of the Hyalomma tick vector is placing new populations at risk for CCHF, and no licensed vaccines or specific antivirals exist to treat CCHF. Furthermore, despite cases of CCHF being reported annually, the host and viral determinants of CCHFV pathogenesis are poorly understood. CCHFV can productively infect a multitude of animal species, yet only humans develop a severe illness. Within human populations, subclinical infections are underappreciated and may represent a substantial proportion of clinical outcomes. Compared with other members of the Bunyavirales order, CCHFV has a more complex genomic organization, with many viral proteins having unclear functions in viral pathogenesis. In recent years, improved animal models have led to increased insights into CCHFV pathogenesis, and several antivirals and vaccines for CCHFV have shown robust efficacy in preclinical models. Translation of these insights and candidate therapeutics to the clinic will hopefully reduce the morbidity and mortality caused by CCHFV.

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References

Simpson D, Knight E, Courtois G, Williams M, WEINBREN M, Kibukamusoke J . Congo virus: a hitherto undescribed virus occurring in Africa. I. Human isolations--clinical notes. East Afr Med J. 1967; 44(2):86-92. View

Casals J . Antigenic similarity between the virus causing Crimean hemorrhagic fever and Congo virus. Proc Soc Exp Biol Med. 1969; 131(1):233-6. DOI: 10.3181/00379727-131-33847. View

Messina J, Pigott D, Golding N, Duda K, Brownstein J, Weiss D . The global distribution of Crimean-Congo hemorrhagic fever. Trans R Soc Trop Med Hyg. 2015; 109(8):503-13. PMC: 4501401. DOI: 10.1093/trstmh/trv050. View

Gargili A, Estrada-Pena A, Spengler J, Lukashev A, Nuttall P, Bente D . The role of ticks in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus: A review of published field and laboratory studies. Antiviral Res. 2017; 144:93-119. PMC: 6047067. DOI: 10.1016/j.antiviral.2017.05.010. View

Lindeborg M, Barboutis C, Ehrenborg C, Fransson T, Jaenson T, Lindgren P . Migratory birds, ticks, and crimean-congo hemorrhagic fever virus. Emerg Infect Dis. 2012; 18(12):2095-7. PMC: 3557898. DOI: 10.3201/eid1812.120718. View

Rainey T, Occi J, Robbins R, Egizi A . Discovery of Haemaphysalis longicornis (Ixodida: Ixodidae) Parasitizing a Sheep in New Jersey, United States. J Med Entomol. 2018; 55(3):757-759. DOI: 10.1093/jme/tjy006. View

Grandi G, Chitimia-Dobler L, Choklikitumnuey P, Strube C, Springer A, Albihn A . First records of adult Hyalomma marginatum and H. rufipes ticks (Acari: Ixodidae) in Sweden. Ticks Tick Borne Dis. 2020; 11(3):101403. DOI: 10.1016/j.ttbdis.2020.101403. View

Spengler J, Bergeron E, Rollin P . Seroepidemiological Studies of Crimean-Congo Hemorrhagic Fever Virus in Domestic and Wild Animals. PLoS Negl Trop Dis. 2016; 10(1):e0004210. PMC: 4704823. DOI: 10.1371/journal.pntd.0004210. View

Gordon S, Linthicum K, Moulton J . Transmission of Crimean-Congo hemorrhagic fever virus in two species of Hyalomma ticks from infected adults to cofeeding immature forms. Am J Trop Med Hyg. 1993; 48(4):576-80. DOI: 10.4269/ajtmh.1993.48.576. View

10.

Garrison A, Alkhovsky al-hovskij sergej vladimirovich S, Avsic-Zupanc T, Bente D, Bergeron E, Burt F . ICTV Virus Taxonomy Profile: . J Gen Virol. 2020; 101(8):798-799. PMC: 7641396. DOI: 10.1099/jgv.0.001485. View

11.

Burt F, Spencer D, Leman P, Patterson B, Swanepoel R . Investigation of tick-borne viruses as pathogens of humans in South Africa and evidence of Dugbe virus infection in a patient with prolonged thrombocytopenia. Epidemiol Infect. 1996; 116(3):353-61. PMC: 2271429. DOI: 10.1017/s0950268800052687. View

12.

Carter S, Surtees R, Walter C, Ariza A, Bergeron E, Nichol S . Structure, function, and evolution of the Crimean-Congo hemorrhagic fever virus nucleocapsid protein. J Virol. 2012; 86(20):10914-23. PMC: 3457148. DOI: 10.1128/JVI.01555-12. View

13.

Guo Y, Wang W, Ji W, Deng M, Sun Y, Zhou H . Crimean-Congo hemorrhagic fever virus nucleoprotein reveals endonuclease activity in bunyaviruses. Proc Natl Acad Sci U S A. 2012; 109(13):5046-51. PMC: 3324003. DOI: 10.1073/pnas.1200808109. View

14.

Jeeva S, Cheng E, Ganaie S, Mir M . Crimean-Congo Hemorrhagic Fever Virus Nucleocapsid Protein Augments mRNA Translation. J Virol. 2017; 91(15). PMC: 5512247. DOI: 10.1128/JVI.00636-17. View

15.

Surtees R, Dowall S, Shaw A, Armstrong S, Hewson R, Carroll M . Heat Shock Protein 70 Family Members Interact with Crimean-Congo Hemorrhagic Fever Virus and Hazara Virus Nucleocapsid Proteins and Perform a Functional Role in the Nairovirus Replication Cycle. J Virol. 2016; 90(20):9305-16. PMC: 5044845. DOI: 10.1128/JVI.00661-16. View

16.

Karlberg H, Tan Y, Mirazimi A . Induction of caspase activation and cleavage of the viral nucleocapsid protein in different cell types during Crimean-Congo hemorrhagic fever virus infection. J Biol Chem. 2010; 286(5):3227-34. PMC: 3030327. DOI: 10.1074/jbc.M110.149369. View

17.

Karlberg H, Tan Y, Mirazimi A . Crimean-Congo haemorrhagic fever replication interplays with regulation mechanisms of apoptosis. J Gen Virol. 2014; 96(Pt 3):538-546. DOI: 10.1099/jgv.0.000011. View

18.

Barnwal B, Karlberg H, Mirazimi A, Tan Y . The Non-structural Protein of Crimean-Congo Hemorrhagic Fever Virus Disrupts the Mitochondrial Membrane Potential and Induces Apoptosis. J Biol Chem. 2015; 291(2):582-92. PMC: 4705379. DOI: 10.1074/jbc.M115.667436. View

19.

Rodrigues R, Paranhos-Baccala G, Vernet G, Peyrefitte C . Crimean-Congo hemorrhagic fever virus-infected hepatocytes induce ER-stress and apoptosis crosstalk. PLoS One. 2012; 7(1):e29712. PMC: 3253088. DOI: 10.1371/journal.pone.0029712. View

20.

Lindquist M, Zeng X, Altamura L, Daye S, Delp K, Blancett C . Exploring Crimean-Congo Hemorrhagic Fever Virus-Induced Hepatic Injury Using Antibody-Mediated Type I Interferon Blockade in Mice. J Virol. 2018; 92(21). PMC: 6189508. DOI: 10.1128/JVI.01083-18. View