Research Trends and Hotspots of Mesenchymal Stromal Cells in Intervertebral Disc Degeneration: a Scientometric Analysis

Overview

Journal EFORT Open Rev

Specialty Orthopedics

Date 2023 Mar 14

PMID 36916744

Authors

Minghe Yao

Tingkui Wu

Beiyu Wang

Affiliations

Soon will be listed here.

Abstract

Mesenchymal stromal cells (MSCs) are important potential candidates for regenerative therapy for intervertebral disc degeneration (IDD). This scientometric study aimed to summarize the main research trends, identify current research hotspots, and measure the networks of the contributors and their scientific productivity. A total of 1102 publications regarding MSC in IDD were recognized from January 2000 to April 2022. The number of records every year followed an overall uptrend with fluctuations. The main trend of research demonstrated the practice of gradually applying MSC-based therapy to IDD with the assistance of advances in biomaterials and IDD pathology. A recent focus on MSC-derived exosomes and notochordal cells was detected. The basic studies in this field were mainly contributed to by Japan, the USA, and European countries, while China dominated in the number of recent publications. Tokai University with Daisuke Sakai was the most productive contributor. Cell biology, tissue engineering, and biomaterials were the categories with deep engagement in research of this field.

References

Ohtori S, Inoue G, Miyagi M, Takahashi K . Pathomechanisms of discogenic low back pain in humans and animal models. Spine J. 2014; 15(6):1347-55. DOI: 10.1016/j.spinee.2013.07.490. View

Sakai D, Schol J . Cell therapy for intervertebral disc repair: Clinical perspective. J Orthop Translat. 2018; 9:8-18. PMC: 5822958. DOI: 10.1016/j.jot.2017.02.002. View

Vadala G, Sowa G, Hubert M, Gilbertson L, Denaro V, Kang J . Mesenchymal stem cells injection in degenerated intervertebral disc: cell leakage may induce osteophyte formation. J Tissue Eng Regen Med. 2011; 6(5):348-55. DOI: 10.1002/term.433. View

Panebianco C, Meyers J, Gansau J, Hom W, Iatridis J . Balancing biological and biomechanical performance in intervertebral disc repair: a systematic review of injectable cell delivery biomaterials. Eur Cell Mater. 2020; 40:239-258. PMC: 7706585. DOI: 10.22203/eCM.v040a15. View

Henriksson H, Svanvik T, Jonsson M, Hagman M, Horn M, Lindahl A . Transplantation of human mesenchymal stems cells into intervertebral discs in a xenogeneic porcine model. Spine (Phila Pa 1976). 2008; 34(2):141-8. DOI: 10.1097/BRS.0b013e31818f8c20. View

Risbud M, Guttapalli A, Tsai T, Lee J, Danielson K, Vaccaro A . Evidence for skeletal progenitor cells in the degenerate human intervertebral disc. Spine (Phila Pa 1976). 2007; 32(23):2537-44. DOI: 10.1097/BRS.0b013e318158dea6. View

Zhao Y, Qin Y, Wu S, Huang D, Hu H, Zhang X . Mesenchymal stem cells regulate inflammatory milieu within degenerative nucleus pulposus cells via p38 MAPK pathway. Exp Ther Med. 2020; 20(5):22. PMC: 7471866. DOI: 10.3892/etm.2020.9150. View

Wang F, Shi R, Cai F, Wang Y, Wu X . Stem Cell Approaches to Intervertebral Disc Regeneration: Obstacles from the Disc Microenvironment. Stem Cells Dev. 2015; 24(21):2479-95. DOI: 10.1089/scd.2015.0158. View

Xia C, Zeng Z, Fang B, Tao M, Gu C, Zheng L . Mesenchymal stem cell-derived exosomes ameliorate intervertebral disc degeneration via anti-oxidant and anti-inflammatory effects. Free Radic Biol Med. 2019; 143:1-15. DOI: 10.1016/j.freeradbiomed.2019.07.026. View

10.

Yao R, Ren C, Wang J, Wu G, Zhu X, Xia Z . Publication Trends of Research on Sepsis and Host Immune Response during 1999-2019: A 20-year Bibliometric Analysis. Int J Biol Sci. 2020; 16(1):27-37. PMC: 6930382. DOI: 10.7150/ijbs.37496. View

11.

Zhang Y, Guo X, Xu P, Kang L, Li J . Bone mesenchymal stem cells transplanted into rabbit intervertebral discs can increase proteoglycans. Clin Orthop Relat Res. 2005; (430):219-26. DOI: 10.1097/01.blo.0000146534.31120.cf. View

12.

Molinos M, Almeida C, Caldeira J, Cunha C, Goncalves R, Barbosa M . Inflammation in intervertebral disc degeneration and regeneration. J R Soc Interface. 2015; 12(108):20150429. PMC: 4528607. DOI: 10.1098/rsif.2015.0429. View

13.

Sabe M, Pillinger T, Kaiser S, Chen C, Taipale H, Tanskanen A . Half a century of research on antipsychotics and schizophrenia: A scientometric study of hotspots, nodes, bursts, and trends. Neurosci Biobehav Rev. 2022; 136:104608. DOI: 10.1016/j.neubiorev.2022.104608. View

14.

Jezierska-Wozniak K, Barczewska M, Habich A, Wojtacha P, Badowska W, Maksymowicz W . The feasibility of the CD271+ and CD271- mesenchymal stromal cell enrichment toward nucleus pulposus-like cells. Folia Histochem Cytobiol. 2017; 55(3):114-123. DOI: 10.5603/FHC.a2017.0013. View

15.

Hiyama A, Mochida J, Iwashina T, Omi H, Watanabe T, Serigano K . Transplantation of mesenchymal stem cells in a canine disc degeneration model. J Orthop Res. 2008; 26(5):589-600. DOI: 10.1002/jor.20584. View

16.

Sakai D, Mochida J, Yamamoto Y, Nomura T, Okuma M, Nishimura K . Transplantation of mesenchymal stem cells embedded in Atelocollagen gel to the intervertebral disc: a potential therapeutic model for disc degeneration. Biomaterials. 2003; 24(20):3531-41. DOI: 10.1016/s0142-9612(03)00222-9. View

17.

Steck E, Bertram H, Abel R, Chen B, Winter A, Richter W . Induction of intervertebral disc-like cells from adult mesenchymal stem cells. Stem Cells. 2005; 23(3):403-11. DOI: 10.1634/stemcells.2004-0107. View

18.

Wu H, Zhou Y, Xu L, Tong L, Wang Y, Liu B . Mapping Knowledge Structure and Research Frontiers of Ultrasound-Induced Blood-Brain Barrier Opening: A Scientometric Study. Front Neurosci. 2021; 15:706105. PMC: 8316975. DOI: 10.3389/fnins.2021.706105. View

19.

Navani A, Manchikanti L, Albers S, Latchaw R, Sanapati J, Kaye A . Responsible, Safe, and Effective Use of Biologics in the Management of Low Back Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines. Pain Physician. 2019; 22(1S):S1-S74. View

20.

Barakat A, Elwell V, Lam K . Stem cell therapy in discogenic back pain. J Spine Surg. 2020; 5(4):561-583. PMC: 6989932. DOI: 10.21037/jss.2019.09.22. View