Regional Homogeneity Alterations in Multifrequency Bands in Patients with Extracranial Multi-organ Tuberculosis: a Prospective Cross-sectional Study

Overview

Journal Quant Imaging Med Surg

Specialty Radiology

Date 2023 Mar 14

PMID 36915302

Authors

Yichuan Wang

Jianjie Wen

Chengcheng Kong

Zexuan Xu

Su Hu

Mengting Li

Xinguang Wang

Hongqiang Zhang

Xize Jia

Qingguo Ding

Jili Wu

Dailun Hou

Affiliations

Soon will be listed here.

Abstract

Background: This study aimed to clarify the spontaneous neural activity in the conventional frequency band (0.01-0.08 Hz) and 2 subfrequency bands (slow-4: 0.027-0.073 Hz; slow-5: 0.01-0.027 Hz) in patients with extracranial multi-organ tuberculosis (EMTB) through regional homogeneity (ReHo) analysis.

Methods: In all, 32 patients with EMTB and 31 healthy controls (HCs) were assessed by resting-state functional magnetic resonance imaging (rs-fMRI) scans to clarify the abnormal spontaneous neural activity through ReHo analysis in the conventional frequency band and 2 subfrequency bands.

Results: Compared with the HCs, the patients with EMTB exhibited decreased ReHo in the left postcentral gyrus [=-4.79; 95% confidence interval (CI): -0.79 to -0.31] and the left superior cerebellum (=-4.45; 95% CI: -0.54 to -0.21) in the conventional band. Conversely, increased ReHo was observed in the right middle occipital gyrus (=3.94; 95% CI: 0.18-0.53). In the slow-4 band, patients with EMTB only exhibited decreased ReHo in the superior cerebellum (=-4.69; 95% CI: -0.54 to -0.22); meanwhile, in the slow-5 band, these patients exhibited decreased ReHo in the right postcentral gyrus (=-3.76; 95% CI: -0.74 to -0.21) and the left superior cerebellum (=-5.20, 95% CI: -0.72 to -0.31). After Bonferroni correction, no significant correlation was observed between the ReHo values in clusters showing significant between-group differences and cognitive test scores.

Conclusions: ReHo showed abnormal synchronous neural activity in patients with EMTB in different frequency bands, which provides a novel understanding of the pathological mechanism of EMTB.

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