Non-falciparum Malaria Infection and IgG Seroprevalence Among Children Under 15 Years in Nigeria, 2018

Overview

Journal Nat Commun

Specialty Biology

Date 2023 Mar 14

PMID 36914649

Authors

Camelia Herman

Colleen M Leonard

Perpetua Uhomoibhi

Mark Maire

Delynn Moss

Uwem Inyang

Ado Abubakar

Abiodun Ogunniyi

Nwando Mba

Stacie M Greby

McPaul I Okoye

Nnaemeka C Iriemenam

Ibrahim Maikore

Laura Steinhardt

Eric Rogier

Affiliations

Soon will be listed here.

Abstract

Plasmodium falciparum (Pf) is the dominant malaria parasite in Nigeria though P. vivax (Pv), P. ovale (Po), and P. malariae (Pm) are also endemic. Blood samples (n = 31,234) were collected from children aged 0-14 years during a 2018 nationwide HIV survey and assayed for Plasmodium antigenemia, Plasmodium DNA, and IgG against Plasmodium MSP1-19 antigens. Of all children, 6.6% were estimated to have Pm infection and 1.4% Po infection with no Pv infections detected. The highest household wealth quintile was strongly protective against infection with Pm (aOR: 0.11, 95% CI: 0.05-0.22) or Po (aOR= 0.01, 0.00-0.10). Overall Pm seroprevalence was 34.2% (95% CI: 33.3-35.2) with lower estimates for Po (12.1%, 11.6-12.5) and Pv (6.3%, 6.0-6.7). Pm seropositivity was detected throughout the country with several local government areas showing >50% seroprevalence. Serological and DNA indicators show widespread exposure of Nigerian children to Pm with lower rates to Po and Pv.

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