C/EBPβ Cooperates with MYB to Maintain the Oncogenic Program of AML Cells

Overview

Journal Oncotarget

Specialty Oncology

Date 2023 Mar 13

PMID 36913305

Authors

Karl-Heinz Klempnauer

Affiliations

Soon will be listed here.

Abstract

Studies on the role of transcription factor MYB in acute myeloid leukemia (AML) have identified MYB as a key regulator of a transcriptional program for self-renewal of AML cells. Recent work summarized here has now highlighted the CCAAT-box/enhancer binding protein beta (C/EBPβ) as an essential factor and potential therapeutic target that cooperates with MYB and coactivator p300 in the maintenance of the leukemic cells.

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