Assessment of Post-infarct Ventricular Septal Defects Through 3D Printing and Statistical Shape Analysis

Overview

Journal J 3D Print Med

Specialty Biomedical Engineering

Date 2023 Mar 13

PMID 36911812

Authors

Ashar Asif

Andrew Iu Shearn

Mark S Turner

Maria V Ordonez

Froso Sophocleous

Ana Mendez-Santos

Israel Valverde

Gianni D Angelini

Massimo Caputo

Mark Ck Hamilton

Giovanni Biglino

Affiliations

Soon will be listed here.

Abstract

Background: Post-infarct ventricular septal defect (PIVSD) is a serious complication of myocardial infarction. We evaluated 3D-printing models in PIVSD clinical assessment and the feasibility of statistical shape modeling for morphological analysis of the defects.

Methods: Models (n = 15) reconstructed from computed tomography data were evaluated by clinicians (n = 8). Statistical shape modeling was performed on 3D meshes to calculate the mean morphological configuration of the defects.

Results: Clinicians' evaluation highlighted the models' utility in displaying defects for interventional/surgical planning, education/training and device development. However, models lack dynamic representation. Morphological analysis was feasible and revealed oval-shaped (n = 12) and complex channel-like (n = 3) defects.

Conclusion: 3D-PIVSD models can complement imaging data for teaching and procedural planning. Statistical shape modeling is feasible in this scenario.

References

Arnaoutakis G, Zhao Y, George T, Sciortino C, McCarthy P, Conte J . Surgical repair of ventricular septal defect after myocardial infarction: outcomes from the Society of Thoracic Surgeons National Database. Ann Thorac Surg. 2012; 94(2):436-43. PMC: 3608099. DOI: 10.1016/j.athoracsur.2012.04.020. View

Biglino G, Capelli C, Leaver L, Schievano S, Taylor A, Wray J . Involving patients, families and medical staff in the evaluation of 3D printing models of congenital heart disease. Commun Med. 2017; 12(2-3):157-69. DOI: 10.1558/cam.28455. View

Garekar S, Bharati A, Chokhandre M, Mali S, Trivedi B, Changela V . Clinical Application and Multidisciplinary Assessment of Three Dimensional Printing in Double Outlet Right Ventricle With Remote Ventricular Septal Defect. World J Pediatr Congenit Heart Surg. 2016; 7(3):344-50. DOI: 10.1177/2150135116645604. View

Durrleman S, Prastawa M, Charon N, Korenberg J, Joshi S, Gerig G . Morphometry of anatomical shape complexes with dense deformations and sparse parameters. Neuroimage. 2014; 101:35-49. PMC: 4871626. DOI: 10.1016/j.neuroimage.2014.06.043. View

Bruse J, Giusti G, Baker C, Cervi E, Hsia T, Taylor A . Statistical Shape Modeling for Cavopulmonary Assist Device Development: Variability of Vascular Graft Geometry and Implications for Hemodynamics. J Med Device. 2017; 11(2). PMC: 5417365. DOI: 10.1115/1.4035865. View

Valverde I, Gomez-Ciriza G, Hussain T, Suarez-Mejias C, Velasco-Forte M, Byrne N . Three-dimensional printed models for surgical planning of complex congenital heart defects: an international multicentre study. Eur J Cardiothorac Surg. 2017; 52(6):1139-1148. DOI: 10.1093/ejcts/ezx208. View

Crenshaw B, Granger C, Birnbaum Y, Pieper K, Morris D, Kleiman N . Risk factors, angiographic patterns, and outcomes in patients with ventricular septal defect complicating acute myocardial infarction. GUSTO-I (Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries) Trial Investigators. Circulation. 2000; 101(1):27-32. DOI: 10.1161/01.cir.101.1.27. View

Pontecorboli G, Biglino G, Milano E, Sophocleous F, Biffi B, Dastidar A . Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy. Comput Methods Biomech Biomed Engin. 2019; 22(14):1103-1106. PMC: 6816475. DOI: 10.1080/10255842.2019.1632836. View

Biglino G, Koniordou D, Gasparini M, Capelli C, Leaver L, Khambadkone S . Piloting the Use of Patient-Specific Cardiac Models as a Novel Tool to Facilitate Communication During Cinical Consultations. Pediatr Cardiol. 2017; 38(4):813-818. PMC: 5388703. DOI: 10.1007/s00246-017-1586-9. View

10.

Turner M, Hamilton M, Morgan G, Martin R . Percutaneous Closure of Post-Myocardial Infarction Ventricular Septal Defect: Patient Selection and Management. Interv Cardiol Clin. 2017; 2(1):173-180. DOI: 10.1016/j.iccl.2012.09.012. View

11.

Biglino G, Capelli C, Koniordou D, Robertshaw D, Leaver L, Schievano S . Use of 3D models of congenital heart disease as an education tool for cardiac nurses. Congenit Heart Dis. 2016; 12(1):113-118. DOI: 10.1111/chd.12414. View

12.

Thiele H, Kaulfersch C, Daehnert I, Schoenauer M, Eitel I, Borger M . Immediate primary transcatheter closure of postinfarction ventricular septal defects. Eur Heart J. 2008; 30(1):81-8. DOI: 10.1093/eurheartj/ehn524. View

13.

Valverde I, Gomez G, Coserria J, Suarez-Mejias C, Uribe S, Sotelo J . 3D printed models for planning endovascular stenting in transverse aortic arch hypoplasia. Catheter Cardiovasc Interv. 2015; 85(6):1006-12. DOI: 10.1002/ccd.25810. View

14.

Shearn A, Yeong M, Richard M, Ordonez M, Pinchbeck H, Milano E . Use of 3D Models in the Surgical Decision-Making Process in a Case of Double-Outlet Right Ventricle With Multiple Ventricular Septal Defects. Front Pediatr. 2019; 7:330. PMC: 6710409. DOI: 10.3389/fped.2019.00330. View

15.

Schievano S, Migliavacca F, Coats L, Khambadkone S, Carminati M, Wilson N . Percutaneous pulmonary valve implantation based on rapid prototyping of right ventricular outflow tract and pulmonary trunk from MR data. Radiology. 2007; 242(2):490-7. DOI: 10.1148/radiol.2422051994. View

16.

Schievano S, Capelli C, Young C, Lurz P, Nordmeyer J, Owens C . Four-dimensional computed tomography: a method of assessing right ventricular outflow tract and pulmonary artery deformations throughout the cardiac cycle. Eur Radiol. 2010; 21(1):36-45. DOI: 10.1007/s00330-010-1913-5. View

17.

Bhatla P, Tretter J, Ludomirsky A, Argilla M, Latson Jr L, Chakravarti S . Utility and Scope of Rapid Prototyping in Patients with Complex Muscular Ventricular Septal Defects or Double-Outlet Right Ventricle: Does it Alter Management Decisions?. Pediatr Cardiol. 2016; 38(1):103-114. DOI: 10.1007/s00246-016-1489-1. View

18.

Sophocleous F, Biffi B, Milano E, Bruse J, Caputo M, Rajakaruna C . Aortic morphological variability in patients with bicuspid aortic valve and aortic coarctation. Eur J Cardiothorac Surg. 2018; 55(4):704-713. PMC: 6459283. DOI: 10.1093/ejcts/ezy339. View

19.

Shirakawa T, Koyama Y, Mizoguchi H, Yoshitatsu M . Morphological analysis and preoperative simulation of a double-chambered right ventricle using 3-dimensional printing technology. Interact Cardiovasc Thorac Surg. 2016; 22(5):688-90. DOI: 10.1093/icvts/ivw009. View

20.

Angelini G, Penny W, Ruttley M, Butchart E, West R, Henderson A . Post-infarction ventricular septal defect: the importance of right ventricular coronary perfusion in determining surgical outcome. Eur J Cardiothorac Surg. 1989; 3(2):156-61. DOI: 10.1016/1010-7940(89)90095-x. View