Thiol-disulfide Balance and Trace Element Levels in Patients with Seasonal Allergic Rhinitis

Overview

Journal Afr Health Sci

Date 2023 Mar 13

PMID 36910410

Authors

Hasan Basri Savas

Huseyin Gunizi

Affiliations

Soon will be listed here.

Abstract

Background: The prevalence of allergic diseases is gradually increasing worldwide. The most common such allergic disease is allergic rhinitis (AR).

Objective: The present study investigated the possible relationship between seasonal AR and the thiol-disulfide balance and zinc and copper levels in adult individuals.

Study Design And Methods: 130 male and female adults were included in the study. The participants' serum thiol-disulfide balance and zinc and copper levels were measured spectrophotometrically using commercial kits. Statistical significance was accepted as p < 0.05 between the groups.

Results: The serum copper (p = 0.001), native thiol (p = 0.006), reduced thiol (p < 0.001), and thiol oxidation reduction ratio (p < 0.001) levels were significantly lower in the seasonal AR group than in the control group.

Conclusion: In AR patients, the low level of copper, which is an important trace element, the deterioration of the thiol-disulfide balance, which represents a unique indicator of the oxidant-antioxidant balance, the increased disulfide level caused by oxidative stress, and the decreased native thiol level can all serve as important biochemical markers.

Citing Articles

Editorial I: So, who wins? It is still: NCDs 3; Infections 2.

Tumwine J Afr Health Sci. 2023; 22(3):i-v.

PMID: 36910355 PMC: 9993260. DOI: 10.4314/ahs.v22i3.1.

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