» Articles » PMID: 36904293

Benefits of Whey Proteins on Type 2 Diabetes Mellitus Parameters and Prevention of Cardiovascular Diseases

Overview
Journal Nutrients
Date 2023 Mar 11
PMID 36904293
Authors
Affiliations
Soon will be listed here.
Abstract

Type 2 diabetes mellitus (T2DM) is a major cause of morbidity and mortality, and it is a major risk factor for the early onset of cardiovascular diseases (CVDs). More than genetics, food, physical activity, walkability, and air pollution are lifestyle factors, which have the greatest impact on T2DM. Certain diets have been shown to be associated with lower T2DM and cardiovascular risk. Diminishing added sugar and processed fats and increasing antioxidant-rich vegetable and fruit intake has often been highlighted, as in the Mediterranean diet. However, less is known about the interest of proteins in low-fat dairy and whey in particular, which have great potential to improve T2DM and could be used safely as a part of a multi-target strategy. This review discusses all the biochemical and clinical aspects of the benefits of high-quality whey, which is now considered a functional food, for prevention and improvement of T2DM and CVDs by insulin- and non-insulin-dependent mechanisms.

Citing Articles

Hypoglycemic Ability of Sericin-Derived Oligopeptides (SDOs) from Yellow Silk Cocoons and Their Physiological Effects on Streptozotocin (STZ)-Induced Diabetic Rats.

Tocharus C, Sutheerawattananonda M Foods. 2024; 13(14).

PMID: 39063270 PMC: 11276246. DOI: 10.3390/foods13142184.


Protein supplementation: the double-edged sword.

Patel V, Aggarwal K, Dhawan A, Singh B, Shah P, Sawhney A Proc (Bayl Univ Med Cent). 2024; 37(1):118-126.

PMID: 38174000 PMC: 10761008. DOI: 10.1080/08998280.2023.2280417.


Effects of supplementation with milk protein on glycemic parameters: a GRADE-assessed systematic review and dose-response meta-analysis.

Mohammadi S, Asbaghi O, Dolatshahi S, Omran H, Amirani N, Koozehkanani F Nutr J. 2023; 22(1):49.

PMID: 37798798 PMC: 10557355. DOI: 10.1186/s12937-023-00878-1.


Whey Improves In Vitro Endothelial Mitochondrial Function and Metabolic Redox Status in Diabetic State.

Martino E, Luce A, Balestrieri A, Mele L, Anastasio C, DOnofrio N Antioxidants (Basel). 2023; 12(6).

PMID: 37372041 PMC: 10295385. DOI: 10.3390/antiox12061311.

References
1.
Hoefle A, Bangert A, Stamfort A, Gedrich K, Rist M, Lee Y . Metabolic responses of healthy or prediabetic adults to bovine whey protein and sodium caseinate do not differ. J Nutr. 2015; 145(3):467-75. DOI: 10.3945/jn.114.199190. View

2.
Power O, Hallihan A, Jakeman P . Human insulinotropic response to oral ingestion of native and hydrolysed whey protein. Amino Acids. 2008; 37(2):333-9. DOI: 10.1007/s00726-008-0156-0. View

3.
Martin W, Armstrong L, Rodriguez N . Dietary protein intake and renal function. Nutr Metab (Lond). 2005; 2:25. PMC: 1262767. DOI: 10.1186/1743-7075-2-25. View

4.
Thornalley P, McLellan A, Lo T, Benn J, Sonksen P . Negative association between erythrocyte reduced glutathione concentration and diabetic complications. Clin Sci (Lond). 1996; 91(5):575-82. DOI: 10.1042/cs0910575. View

5.
Zamora-Mendoza R, Rosas-Vargas H, Ramos-Cervantes M, Garcia-Zuniga P, Perez-Lorenzana H, Mendoza-Lorenzo P . Dysregulation of mitochondrial function and biogenesis modulators in adipose tissue of obese children. Int J Obes (Lond). 2017; 42(4):618-624. DOI: 10.1038/ijo.2017.274. View