Current Practice in Pediatric Cow's Milk Protein Allergy-Immunological Features and Beyond

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Mar 11

PMID 36902457

Authors

Vanessza Emmert

Dominika Lendvai-Emmert

Kata Eklics

Viktoria Premusz

Gergely Peter Toth

Affiliations

Soon will be listed here.

Abstract

Cow's milk protein allergy is one of the most common pediatric food allergies. It poses a significant socioeconomic burden in industrialized countries and has a profound effect on the quality of life of affected individuals and their families. Diverse immunologic pathways can lead to the clinical symptoms of cow's milk protein allergy; some of the pathomechanisms are known in detail, but others need further elucidation. A comprehensive understanding of the development of food allergies and the features of oral tolerance could have the potential to unlock more precise diagnostic tools and novel therapeutic approaches for patients with cow's milk protein allergy.

Citing Articles

Clinical, laboratory, and therapeutic differences between immunoglobulin E-mediated and non-immunoglobulin E-mediated cow's milk protein allergy in children.

Isa H, Abdulnabi M, Naser N, Lahmda F, AlAnsari N, Isa Z World J Clin Pediatr. 2025; 14(1):100386.

PMID: 40059903 PMC: 11686578. DOI: 10.5409/wjcp.v14.i1.100386.

Risks of dairy derived excipients in medications for lactose intolerant and cow milk protein allergic patients.

Figueiredo A, Auxtero M, Santo M, Casimiro A, Costa I Sci Rep. 2024; 14(1):15631.

PMID: 38972872 PMC: 11228012. DOI: 10.1038/s41598-024-66380-8.

Fecal calprotectin in pediatric gastrointestinal diseases: Pros and cons.

Al-Beltagi M, Saeed N, Bediwy A, Elbeltagi R World J Clin Pediatr. 2024; 13(2):93341.

PMID: 38948001 PMC: 11212754. DOI: 10.5409/wjcp.v13.i2.93341.

Recent Mechanistic Studies in Allergic Diseases.

Sindher S, Sharma R, Yarlagadda M, Chin A, Chinthrajah R Int J Mol Sci. 2023; 24(18).

PMID: 37762615 PMC: 10531635. DOI: 10.3390/ijms241814312.

References

Zhang S, Sicherer S, Berin M, Agyemang A . Pathophysiology of Non-IgE-Mediated Food Allergy. Immunotargets Ther. 2022; 10:431-446. PMC: 8721028. DOI: 10.2147/ITT.S284821. View

Frischmeyer-Guerrerio P, Keet C, Guerrerio A, Chichester K, Bieneman A, Hamilton R . Modulation of dendritic cell innate and adaptive immune functions by oral and sublingual immunotherapy. Clin Immunol. 2014; 155(1):47-59. PMC: 4252363. DOI: 10.1016/j.clim.2014.08.006. View

Palomares O, Ruckert B, Jartti T, Kucuksezer U, Puhakka T, Gomez E . Induction and maintenance of allergen-specific FOXP3+ Treg cells in human tonsils as potential first-line organs of oral tolerance. J Allergy Clin Immunol. 2011; 129(2):510-20, 520.e1-9. DOI: 10.1016/j.jaci.2011.09.031. View

Qamer S, Deshmukh M, Patole S . Probiotics for cow's milk protein allergy: a systematic review of randomized controlled trials. Eur J Pediatr. 2019; 178(8):1139-1149. DOI: 10.1007/s00431-019-03397-6. View

Linhart B, Freidl R, Elisyutina O, Khaitov M, Karaulov A, Valenta R . Molecular Approaches for Diagnosis, Therapy and Prevention of Cow´s Milk Allergy. Nutrients. 2019; 11(7). PMC: 6683018. DOI: 10.3390/nu11071492. View

Warren C, Jiang J, Gupta R . Epidemiology and Burden of Food Allergy. Curr Allergy Asthma Rep. 2020; 20(2):6. PMC: 7883751. DOI: 10.1007/s11882-020-0898-7. View

McDole J, Wheeler L, McDonald K, Wang B, Konjufca V, Knoop K . Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine. Nature. 2012; 483(7389):345-9. PMC: 3313460. DOI: 10.1038/nature10863. View

Tanabe S . Analysis of food allergen structures and development of foods for allergic patients. Biosci Biotechnol Biochem. 2008; 72(3):649-59. DOI: 10.1271/bbb.70708. View

Popielarz M, Krogulska A . The importance of component-resolved diagnostics in IgE-mediated cow's milk allergy. Allergol Immunopathol (Madr). 2021; 49(3):30-41. DOI: 10.15586/aei.v49i3.74. View

10.

Schappi M, Borrelli O, Knafelz D, Williams S, Smith V, Milla P . Mast cell-nerve interactions in children with functional dyspepsia. J Pediatr Gastroenterol Nutr. 2008; 47(4):472-80. DOI: 10.1097/MPG.0b013e318186008e. View

11.

Giannetti A, Toschi Vespasiani G, Ricci G, Miniaci A, Di Palmo E, Pession A . Cow's Milk Protein Allergy as a Model of Food Allergies. Nutrients. 2021; 13(5). PMC: 8147250. DOI: 10.3390/nu13051525. View

12.

Lendvai-Emmert D, Emmert V, Makai A, Fusz K, Premusz V, Eklics K . Fecal calprotectin levels in pediatric cow's milk protein allergy. Front Pediatr. 2022; 10:945212. PMC: 9397604. DOI: 10.3389/fped.2022.945212. View

13.

Tuano K, Davis C . Utility of Component-Resolved Diagnostics in Food Allergy. Curr Allergy Asthma Rep. 2015; 15(6):32. DOI: 10.1007/s11882-015-0534-0. View

14.

Arasi S, Cafarotti A, Fiocchi A . Cow's milk allergy. Curr Opin Allergy Clin Immunol. 2022; 22(3):181-187. DOI: 10.1097/ACI.0000000000000823. View

15.

Mucida D, Kutchukhidze N, Erazo A, Russo M, Lafaille J, Curotto de Lafaille M . Oral tolerance in the absence of naturally occurring Tregs. J Clin Invest. 2005; 115(7):1923-33. PMC: 1142115. DOI: 10.1172/JCI24487. View

16.

Nadeau K, Schneider L, Hoyte L, Borras I, Umetsu D . Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy. J Allergy Clin Immunol. 2011; 127(6):1622-4. PMC: 3396422. DOI: 10.1016/j.jaci.2011.04.009. View

17.

Gonsalves N . Eosinophilic Gastrointestinal Disorders. Clin Rev Allergy Immunol. 2019; 57(2):272-285. DOI: 10.1007/s12016-019-08732-1. View

18.

Brough H, Nadeau K, Sindher S, Alkotob S, Chan S, Bahnson H . Epicutaneous sensitization in the development of food allergy: What is the evidence and how can this be prevented?. Allergy. 2020; 75(9):2185-2205. PMC: 7494573. DOI: 10.1111/all.14304. View

19.

Ibanez-Sandin M, Escudero C, Candon Morillo R, Lasa E, Marchan-Martin E, Sanchez-Garcia S . Oral immunotherapy in severe cow's milk allergic patients treated with omalizumab: Real life survey from a Spanish registry. Pediatr Allergy Immunol. 2021; 32(6):1287-1295. DOI: 10.1111/pai.13517. View

20.

De Boissieu D, Dupont C . Sublingual immunotherapy for cow's milk protein allergy: a preliminary report. Allergy. 2006; 61(10):1238-9. DOI: 10.1111/j.1398-9995.2006.01196.x. View