Histaminergic System and Inflammation-Related Genes in Normal Large Intestine and Tissues: Transcriptional Profiles and Relations

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Mar 11

PMID 36902343

Authors

Grazyna Janikowska

Tomasz Janikowski

Marta Plato

Urszula Mazurek

Joanna Orchel

Mieszko Opilka

Zbigniew Lorenc

Affiliations

Soon will be listed here.

Abstract

Transcriptional analyses such as microarray data have contributed to the progress in the diagnostics and therapy of colorectal cancer (CRC). The need for such research is still present because of the disease being common in both men and women with a high second position in cancer rankings. Little is known about the relations between the histaminergic system and inflammation in the large intestine and CRC. Therefore, the aim of this study was to evaluate the expression of genes related to the histaminergic system and inflammation in the CRC tissues at three cancer development designs: all tested CRC samples, low (LCS) and high (HCS) clinical stage, and four clinical stages (CSI-CSIV), to the control. The research was carried out at the transcriptomic level, analysing hundreds of mRNAs from microarrays, as well as carrying out RT-PCR analysis of histaminergic receptors. The following histaminergic mRNAs: , , , and inflammation-related: , , , , , , , were distinguished. Among all analysed transcripts, can be considered the most promising diagnostic marker in the early stage of CRC. The results showed 59 correlations between differentiating genes of the histaminergic system and inflammation in the control, control and CRC, and CRC. The tests confirmed the presence of all histamine receptor transcripts in both the control and colorectal . Significant differences in expression were stated for and in the advanced stages of CRC . The relations between the histaminergic system and inflammation-linked genes in both the control and the CRC have been observed.

References

Bule P, Aguiar S, Aires-da-Silva F, Dias J . Chemokine-Directed Tumor Microenvironment Modulation in Cancer Immunotherapy. Int J Mol Sci. 2021; 22(18). PMC: 8464715. DOI: 10.3390/ijms22189804. View

Majdalawieh A, Massri M, Ro H . AEBP1 is a Novel Oncogene: Mechanisms of Action and Signaling Pathways. J Oncol. 2020; 2020:8097872. PMC: 7273425. DOI: 10.1155/2020/8097872. View

Yang L, Tao Y, Ou D, Wang W, Chang Z, Wu F . Increased expression of Wiskott-Aldrich syndrome protein family verprolin-homologous protein 2 correlated with poor prognosis of hepatocellular carcinoma. Clin Cancer Res. 2006; 12(19):5673-9. DOI: 10.1158/1078-0432.CCR-06-0022. View

Castelo Branco A, Yoshikawa F, Pietrobon A, Sato M . Role of Histamine in Modulating the Immune Response and Inflammation. Mediators Inflamm. 2018; 2018:9524075. PMC: 6129797. DOI: 10.1155/2018/9524075. View

Iwaya K, Norio K, Mukai K . Coexpression of Arp2 and WAVE2 predicts poor outcome in invasive breast carcinoma. Mod Pathol. 2007; 20(3):339-43. DOI: 10.1038/modpathol.3800741. View

Lukaszewicz-Zajac M, Mroczko B . Circulating Biomarkers of Colorectal Cancer (CRC)-Their Utility in Diagnosis and Prognosis. J Clin Med. 2021; 10(11). PMC: 8199026. DOI: 10.3390/jcm10112391. View

Schirmer B, Rother T, Bruesch I, Bleich A, Werlein C, Jonigk D . Genetic Deficiency of the Histamine H-Receptor Reduces Experimental Colorectal Carcinogenesis in Mice. Cancers (Basel). 2020; 12(4). PMC: 7226035. DOI: 10.3390/cancers12040912. View

Tan F, He D, Hu K, Wang D, Zhang S, Li J . WAVE2 Enhanced Hepatic Stellate Cells Activity in Colorectal Liver Metastases. Cancer Manag Res. 2020; 12:7671-7680. PMC: 7455535. DOI: 10.2147/CMAR.S259125. View

Lee S, Meyerhardt J . Impact of Diet and Exercise on Colorectal Cancer. Hematol Oncol Clin North Am. 2022; 36(3):471-489. DOI: 10.1016/j.hoc.2022.02.004. View

10.

Offenberg H, Brunner N, Mansilla F, Orntoft Torben F, Birkenkamp-Demtroder K . TIMP-1 expression in human colorectal cancer is associated with TGF-B1, LOXL2, INHBA1, TNF-AIP6 and TIMP-2 transcript profiles. Mol Oncol. 2009; 2(3):233-40. PMC: 5527800. DOI: 10.1016/j.molonc.2008.06.003. View

11.

Long J, Xie Y, Yin J, Lu W, Fang S . SphK1 promotes tumor cell migration and invasion in colorectal cancer. Tumour Biol. 2015; 37(5):6831-6. DOI: 10.1007/s13277-015-4542-4. View

12.

Cricco G, Martin G, Medina V, Nunez M, Gutierrez A, Cocca C . Histamine regulates the MAPK pathway via the H(2) receptor in PANC-1 human cells. Inflamm Res. 2004; 53 Suppl 1:S65-6. DOI: 10.1007/s00011-003-0331-4. View

13.

Yip K, Das P, Suria D, Lim C, Ng G, Liew C . A case-controlled validation study of a blood-based seven-gene biomarker panel for colorectal cancer in Malaysia. J Exp Clin Cancer Res. 2010; 29:128. PMC: 2949823. DOI: 10.1186/1756-9966-29-128. View

14.

Gunter M, Alhomoud S, Arnold M, Brenner H, Burn J, Casey G . Meeting report from the joint IARC-NCI international cancer seminar series: a focus on colorectal cancer. Ann Oncol. 2019; 30(4):510-519. PMC: 6503626. DOI: 10.1093/annonc/mdz044. View

15.

Nguyen P, Cho J . Pathophysiological Roles of Histamine Receptors in Cancer Progression: Implications and Perspectives as Potential Molecular Targets. Biomolecules. 2021; 11(8). PMC: 8392479. DOI: 10.3390/biom11081232. View

16.

Iwaya K, Oikawa K, Semba S, Tsuchiya B, Mukai Y, Otsubo T . Correlation between liver metastasis of the colocalization of actin-related protein 2 and 3 complex and WAVE2 in colorectal carcinoma. Cancer Sci. 2007; 98(7):992-9. PMC: 11158612. DOI: 10.1111/j.1349-7006.2007.00488.x. View

17.

Semba S, Iwaya K, Matsubayashi J, Serizawa H, Kataba H, Hirano T . Coexpression of actin-related protein 2 and Wiskott-Aldrich syndrome family verproline-homologous protein 2 in adenocarcinoma of the lung. Clin Cancer Res. 2006; 12(8):2449-54. DOI: 10.1158/1078-0432.CCR-05-2566. View

18.

Tiligada E, Ennis M . Histamine pharmacology: from Sir Henry Dale to the 21st century. Br J Pharmacol. 2018; 177(3):469-489. PMC: 7012941. DOI: 10.1111/bph.14524. View

19.

Li L, Yang L, Chen X, Chen X, Diao L, Zeng Y . TNFAIP6 defines the MSC subpopulation with enhanced immune suppression activities. Stem Cell Res Ther. 2022; 13(1):479. PMC: 9509641. DOI: 10.1186/s13287-022-03176-5. View

20.

Zanini S, Giovinazzo F, Alaimo D, Lawrence B, Pfragner R, Bassi C . GNA15 expression in small intestinal neuroendocrine neoplasia: functional and signalling pathway analyses. Cell Signal. 2015; 27(5):899-907. DOI: 10.1016/j.cellsig.2015.02.001. View