Degranulation of Murine Resident Cochlear Mast Cells: A Possible Factor Contributing to Cisplatin-Induced Ototoxicity and Neurotoxicity

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2023 Mar 11

PMID 36902051

Authors

Betul Karayay

Heidi Olze

Agnieszka J Szczepek

Affiliations

Soon will be listed here.

Abstract

Permanent hearing loss is one of cisplatin's adverse effects, affecting 30-60% of cancer patients treated with that drug. Our research group recently identified resident mast cells in rodents' cochleae and observed that the number of mast cells changed upon adding cisplatin to cochlear explants. Here, we followed that observation and found that the murine cochlear mast cells degranulate in response to cisplatin and that the mast cell stabilizer cromoglicic acid (cromolyn) inhibits this process. Additionally, cromolyn significantly prevented cisplatin-induced loss of auditory hair cells and spiral ganglion neurons. Our study provides the first evidence for the possible mast cell participation in cisplatin-induced damage to the inner ear.

Citing Articles

Mast Cells in Human Health and Diseases 2.0.

Traina G Int J Mol Sci. 2024; 25(12).

PMID: 38928149 PMC: 11203736. DOI: 10.3390/ijms25126443.

Molecular Characteristics of Cisplatin-Induced Ototoxicity and Therapeutic Interventions.

Tan W, Vlajkovic S Int J Mol Sci. 2023; 24(22).

PMID: 38003734 PMC: 10671929. DOI: 10.3390/ijms242216545.

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