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How to Tackle Bacteriophages: The Review of Approaches with Mechanistic Insight

Overview
Journal Int J Mol Sci
Publisher MDPI
Date 2023 Mar 11
PMID 36901878
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Abstract

Bacteriophage-based applications have a renaissance today, increasingly marking their use in industry, medicine, food processing, biotechnology, and more. However, phages are considered resistant to various harsh environmental conditions; besides, they are characterized by high intra-group variability. Phage-related contaminations may therefore pose new challenges in the future due to the wider use of phages in industry and health care. Therefore, in this review, we summarize the current knowledge of bacteriophage disinfection methods, as well as highlight new technologies and approaches. We discuss the need for systematic solutions to improve bacteriophage control, taking into account their structural and environmental diversity.

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References
1.
Potrykus K, Wegrzyn G, Hernandez V . Multiple mechanisms of transcription inhibition by ppGpp at the lambdap(R) promoter. J Biol Chem. 2002; 277(46):43785-91. DOI: 10.1074/jbc.M208768200. View

2.
Nowicki D, Maciag-Dorszynska M, Kobiela W, Herman-Antosiewicz A, Wegrzyn A, Szalewska-Palasz A . Phenethyl isothiocyanate inhibits shiga toxin production in enterohemorrhagic Escherichia coli by stringent response induction. Antimicrob Agents Chemother. 2014; 58(4):2304-15. PMC: 4023782. DOI: 10.1128/AAC.02515-13. View

3.
Zheng X, Shen Z, Cheng C, Shi L, Cheng R, Yuan D . Photocatalytic disinfection performance in virus and virus/bacteria system by Cu-TiO nanofibers under visible light. Environ Pollut. 2018; 237:452-459. DOI: 10.1016/j.envpol.2018.02.074. View

4.
Brady-Estevez A, Kang S, Elimelech M . A single-walled-carbon-nanotube filter for removal of viral and bacterial pathogens. Small. 2008; 4(4):481-4. DOI: 10.1002/smll.200700863. View

5.
Hardy A, Kever L, Frunzke J . Antiphage small molecules produced by bacteria - beyond protein-mediated defenses. Trends Microbiol. 2022; 31(1):92-106. DOI: 10.1016/j.tim.2022.08.001. View