Testing Relationship Between Tea Intake and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus: a Mendelian Randomization Study

Overview

Journal Adv Rheumatol

Publisher Biomed Central

Specialty Rheumatology

Date 2023 Mar 10

PMID 36899398

Authors

Rong-Bin Lu

Jian Huang

Affiliations

Soon will be listed here.

Abstract

Background: We performed Mendelian randomization (MR) to assess the causal effect of tea intake on rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).

Methods: Genetic instruments for tea intake were obtained from a large genome-wide association study (GWAS) dataset of the UK Biobank. Genetic association estimates for RA (6236 cases and 147,221 controls) and SLE (538 cases and 213,145 controls) were obtained from the FinnGen study through the IEU GWAS database.

Results: MR analyses using the inverse-variance weighted method showed that tea intake was not associated with risk of RA [odds ratio (OR) per standard deviation increment in genetically predicted tea intake = 0.997, 95% confidence interval (CI) 0.658-1.511] and SLE (OR per standard deviation increment in genetically predicted tea intake = 0.961, 95% CI 0.299-3.092). Weighted median, weighted mode, MR-Egger, leave-one-out and multivariable MR controlling for several confounding factors including current tobacco smoking, coffee intake, and alcoholic drinks per week yielded completely consistent results. No evidence of heterogeneity and pleiotropy was found.

Conclusion: Our MR study did not suggest a causal effect of genetically predicted tea intake on RA and SLE.

References

Cush J . Rheumatoid Arthritis: Early Diagnosis and Treatment. Rheum Dis Clin North Am. 2022; 48(2):537-547. DOI: 10.1016/j.rdc.2022.02.010. View

Barber M, Drenkard C, Falasinnu T, Hoi A, Mak A, Kow N . Global epidemiology of systemic lupus erythematosus. Nat Rev Rheumatol. 2021; 17(9):515-532. PMC: 8982275. DOI: 10.1038/s41584-021-00668-1. View

Mathias L, Stohl W . Systemic lupus erythematosus (SLE): emerging therapeutic targets. Expert Opin Ther Targets. 2020; 24(12):1283-1302. DOI: 10.1080/14728222.2020.1832464. View

Neyestani T, Gharavi A, Kalayi A . Selective effects of tea extract and its phenolic compounds on human peripheral blood mononuclear cell cytokine secretions. Int J Food Sci Nutr. 2008; 60 Suppl 1:79-88. DOI: 10.1080/09637480802158184. View

Peairs A, Dai R, Gan L, Shimp S, Rylander M, Li L . Epigallocatechin-3-gallate (EGCG) attenuates inflammation in MRL/lpr mouse mesangial cells. Cell Mol Immunol. 2010; 7(2):123-32. PMC: 4001894. DOI: 10.1038/cmi.2010.1. View

Banuls-Mirete M, Ogdie A, Guma M . Micronutrients: Essential Treatment for Inflammatory Arthritis?. Curr Rheumatol Rep. 2020; 22(12):87. PMC: 8078476. DOI: 10.1007/s11926-020-00962-z. View

Liu D, Li P, Song S, Liu Y, Wang Q, Chang Y . Pro-apoptotic effect of epigallo-catechin-3-gallate on B lymphocytes through regulating BAFF/PI3K/Akt/mTOR signaling in rats with collagen-induced arthritis. Eur J Pharmacol. 2012; 690(1-3):214-25. DOI: 10.1016/j.ejphar.2012.06.026. View

Wu D, Wang J, Pae M, Meydani S . Green tea EGCG, T cells, and T cell-mediated autoimmune diseases. Mol Aspects Med. 2011; 33(1):107-18. DOI: 10.1016/j.mam.2011.10.001. View

Riegsecker S, Wiczynski D, Kaplan M, Ahmed S . Potential benefits of green tea polyphenol EGCG in the prevention and treatment of vascular inflammation in rheumatoid arthritis. Life Sci. 2013; 93(8):307-12. PMC: 3768132. DOI: 10.1016/j.lfs.2013.07.006. View

10.

Tsai P, Ka S, Chang J, Chen H, Shui H, Li C . Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation. Free Radic Biol Med. 2011; 51(3):744-54. DOI: 10.1016/j.freeradbiomed.2011.05.016. View

11.

Mikuls T, Cerhan J, Criswell L, Merlino L, Mudano A, Burma M . Coffee, tea, and caffeine consumption and risk of rheumatoid arthritis: results from the Iowa Women's Health Study. Arthritis Rheum. 2002; 46(1):83-91. DOI: 10.1002/1529-0131(200201)46:1<83::AID-ART10042>3.0.CO;2-D. View

12.

Karlson E, Mandl L, Aweh G, Grodstein F . Coffee consumption and risk of rheumatoid arthritis. Arthritis Rheum. 2003; 48(11):3055-60. DOI: 10.1002/art.11306. View

13.

Washio M, Fujii T, Kuwana M, Kawaguchi Y, Mimori A, Horiuchi T . Lifestyle and other related factors for the development of mixed connective tissue disease among Japanese females in comparison with systemic lupus erythematosus. Mod Rheumatol. 2014; 24(5):788-92. DOI: 10.3109/14397595.2013.863442. View

14.

Rambod M, Nazarinia M, Raieskarimian F . The impact of dietary habits on the pathogenesis of rheumatoid arthritis: a case-control study. Clin Rheumatol. 2018; 37(10):2643-2648. DOI: 10.1007/s10067-018-4151-x. View

15.

Lamichhane D, Collins C, Constantinescu F, Walitt B, Pettinger M, Parks C . Coffee and Tea Consumption in Relation to Risk of Rheumatoid Arthritis in the Women's Health Initiative Observational Cohort. J Clin Rheumatol. 2018; 25(3):127-132. PMC: 6195489. DOI: 10.1097/RHU.0000000000000788. View

16.

Westerlind H, Palmqvist I, Saevarsdottir S, Alfredsson L, Klareskog L, Di Giuseppe D . Is tea consumption associated with reduction of risk of rheumatoid arthritis? A Swedish case-control study. Arthritis Res Ther. 2021; 23(1):209. PMC: 8349003. DOI: 10.1186/s13075-021-02583-y. View

17.

Bae S, Lee Y . Coffee consumption and the risk of rheumatoid arthritis and systemic lupus erythematosus: a Mendelian randomization study. Clin Rheumatol. 2018; 37(10):2875-2879. DOI: 10.1007/s10067-018-4278-9. View

18.

Bae S, Lee Y . Alcohol intake and risk of rheumatoid arthritis: a Mendelian randomization study. Z Rheumatol. 2018; 78(8):791-796. DOI: 10.1007/s00393-018-0537-z. View

19.

Jiang X, Alfredsson L . Modifiable environmental exposure and risk of rheumatoid arthritis-current evidence from genetic studies. Arthritis Res Ther. 2020; 22(1):154. PMC: 7310443. DOI: 10.1186/s13075-020-02253-5. View

20.

Jiang X, Zhu Z, Manouchehrinia A, Olsson T, Alfredsson L, Kockum I . Alcohol Consumption and Risk of Common Autoimmune Inflammatory Diseases-Evidence From a Large-Scale Genetic Analysis Totaling 1 Million Individuals. Front Genet. 2021; 12:687745. PMC: 8258244. DOI: 10.3389/fgene.2021.687745. View