Noninvasive Assessment of Myocardial Work During Left Ventricular Isovolumic Relaxation in Patients with Diastolic Dysfunction

Overview

Journal BMC Cardiovasc Disord

Publisher Biomed Central

Specialty Cardiology & Vascular Diseases

Date 2023 Mar 10

PMID 36899310

Authors

Ying Guo

Xiang Wang

Chen-Guang Yang

Xu-Yang Meng

Yi Li

Chen-Xi Xia

Tao Xu

Si-Xian Weng

You Zhong

Rui-Sheng Zhang

Fang Wang

Affiliations

Soon will be listed here.

Abstract

Background: This study aims to investigate the value of myocardial work (MW) parameters during the isovolumic relaxation (IVR) period in patients with left ventricular diastolic dysfunction (LVDD).

Methods: This study prospectively recruited 448 patients with risks for LVDD and 95 healthy subjects. An additional 42 patients with invasive measurements of left ventricular (LV) diastolic function were prospectively included. The MW parameters during IVR were noninvasively measured using EchoPAC.

Results: The total myocardial work during IVR (MW), myocardial constructive work during IVR (MCW), myocardial wasted work during IVR (MWW), and myocardial work efficiency during IVR (MWE) of these patients were 122.5 ± 60.1 mmHg%, 85.7 ± 47.8 mmHg%, 36.7 ± 30.6 mmHg%, and 69.4 ± 17.8%, respectively. The MW during IVR was significantly different between patients and healthy subjects. For patients, MWE and MCW were significantly correlated with the LV E/e' ratio and left atrial volume index, MWE exhibited a significant correlation with the maximal rate of decrease in LV pressure (dp/dt per min) and tau, and the MWE corrected by IVRT also exhibited a significant correlation with tau.

Conclusions: MW during IVR significantly changes in patients with risks for LVDD, and is correlated to LV conventional diastolic indices, including dp/dt min and tau. Noninvasive MW during IVR may be a promising tool to evaluate the LV diastolic function.

Citing Articles

Myocardial work alterations with progressive left ventricular hypertrophy in patients with hypertension.

Fan J, Wang H, Zhang Y, Ma C, Zhou B J Clin Hypertens (Greenwich). 2024; 26(9):1045-1053.

PMID: 39007716 PMC: 11488308. DOI: 10.1111/jch.14855.

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