The Effects of N-methyladenosine RNA Methylation on the Nervous System

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 2023 Mar 10

PMID 36899139

Authors

Nan Shao

Ting Ye

Weiting Xuan

Meng Zhang

Qian Chen

Juan Liu

Peng Zhou

Hang Song

Biao Cai

Affiliations

Soon will be listed here.

Abstract

Epitranscriptomics, also known as "RNA epigenetics", is a type of chemical modification that regulates RNA. RNA methylation is a significant discovery after DNA and histone methylation. The dynamic reversible process of mA involves methyltransferases (writers), mA binding proteins (readers), as well as demethylases (erasers). We summarized the current research status of mA RNA methylation in the neural stem cells' growth, synaptic and axonal function, brain development, learning and memory, neurodegenerative diseases, and glioblastoma. This review aims to provide a theoretical basis for studying the mechanism of mA methylation and finding its potential therapeutic targets in nervous system diseases.

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