Development of Selective IgM Deficiency in Systemic Lupus Erythematosus Patients with Disease of Long Duration

Overview

Journal Arthritis Rheum

Specialty Rheumatology

Date 1987 Nov 1

PMID 3689463

Citations 17

Authors

O Saiki

Y Saeki

T Tanaka

S Doi

H Hara

S Negoro

T Igarashi

S Kishimoto

Affiliations

Soon will be listed here.

Abstract

Statistical analysis of serum immunoglobulin levels in 54 systemic lupus erythematosus (SLE) patients showed a decrease in serum IgM (normal 77 +/- 26 mg/dl; P less than 0.001) that was closely related to disease duration. The longer the duration of SLE, the more striking the decrease in serum levels of IgM (r = -0.74, P less than 0.01). Selective IgM deficiency (less than 47 mg/dl) occurred in SLE patients whose disease was clinically inactive or less active.

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