The Question of Survival or Death: What Is the Role of Autophagy in Acute Myeloid Leukemia (AML)?

Overview

Journal Int J Hematol Oncol Stem Cell Res

Specialty Hematology

Date 2023 Mar 8

PMID 36883106

Authors

Atousa Haghi

Mahnaz Mohammadi Kian

Mahdieh Salemi

Mohammad Reza Eghdami

Mohsen Nikbakht

Affiliations

Soon will be listed here.

Abstract

Autophagy plays a critical role in balancing sources of energy in response to harsh conditions and nutrient deprivation. Autophagy allows cells to survive in harsh condition and also serve as a death mechanism. Any dysregulation in autophagy signaling may lead to several disorders. Autophagy has been proposed to explain chemotherapy resistance in acute myeloid leukemia (AML). This signaling pathway can either act as a tumor suppressive function or chemo-resistance mechanism. Conventional chemotherapy drugs enhance apoptosis and indicate clinical benefit, but in some cases, relapse and chemotherapy resistance are observed. In leukemia, autophagy may promote cell survival in response to chemotherapy drugs. Therefore, new strategies by inhibiting or activating autophagy may find a broad application for treating leukemia and may significantly enhance clinical outcomes. In this review, we discussed the dimensional role of autophagy in leukemia.

Citing Articles

Landscape of FLT3 Variations Associated with Structural and Functional Impact on Acute Myeloid Leukemia: A Computational Study.

Mirza Z, Al-Saedi D, Alganmi N, Karim S Int J Mol Sci. 2024; 25(6).

PMID: 38542393 PMC: 10970727. DOI: 10.3390/ijms25063419.

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