Association of General and Central Obesity, and Their Changes with Risk of Knee Osteoarthritis: a Nationwide Population-based Cohort Study

Overview

Journal Sci Rep

Specialty Science

Date 2023 Mar 7

PMID 36882508

Authors

DoJoon Park

Yong-Moon Park

Seung-Hyun Ko

Kang-Se Hyun

Youn-Ho Choi

Dong-Uk Min

Kyungdo Han

Hae-Seok Koh

Affiliations

Soon will be listed here.

Abstract

In this study, we aimed to evaluate the association between general and central obesity, and their changes with risk of knee osteoarthritis (OA) using retrospective cohort data collected from the Korean National Health Insurance Service. We studied 1,139,463 people aged 50 and over who received a health examination in 2009. To evaluate the association between general and/or central obesity and knee OA risk, a Cox proportional hazard models were used. Additionally, we investigate knee OA risk according to the change in obesity status over 2 years for subjects who had undergone health examinations for 2 consecutive years. General obesity without central obesity (HR 1.281, 95% CI 1.270-1.292) and central obesity without general obesity (HR 1.167, 95% CI 1.150-1.184) were associated with increased knee OA risk than the comparison group. Individuals with both general with central obesity had the highest risk (HR 1.418, 95% CI 1.406-1.429). This association was more pronounced in women and younger age group. Remarkably, the remission of general or central obesity over two years was associated with decreased knee OA risk (HR 0.884; 95% CI 0.867-0.902; HR 0.900; 95% CI 0.884-0.916, respectively). The present study found that both general and central obesity were associated with increased risk of knee OA and the risk was highest when the two types of obesity were accompanied. Changes in obesity status have been confirmed to alter the risk of knee OA.

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References

Lee K, Hwang I, Han K, Jung J, Seo M . Waist circumference and risk of breast cancer in Korean women: A nationwide cohort study. Int J Cancer. 2017; 142(8):1554-1559. DOI: 10.1002/ijc.31180. View

Kang S, Choi E, Han K, Lee S, Lim W, Cha M . Underweight is a risk factor for atrial fibrillation: A nationwide population-based study. Int J Cardiol. 2016; 215:449-56. DOI: 10.1016/j.ijcard.2016.04.036. View

Gualillo O . Further evidence for leptin involvement in cartilage homeostases. Osteoarthritis Cartilage. 2007; 15(8):857-60. DOI: 10.1016/j.joca.2007.04.015. View

van Saase J, Vandenbroucke J, van Romunde L, VALKENBURG H . Osteoarthritis and obesity in the general population. A relationship calling for an explanation. J Rheumatol. 1988; 15(7):1152-8. View

Wills A, Black S, Cooper R, Coppack R, Hardy R, Martin K . Life course body mass index and risk of knee osteoarthritis at the age of 53 years: evidence from the 1946 British birth cohort study. Ann Rheum Dis. 2011; 71(5):655-60. PMC: 3329229. DOI: 10.1136/ard.2011.154021. View

Ouchi N, Parker J, Lugus J, Walsh K . Adipokines in inflammation and metabolic disease. Nat Rev Immunol. 2011; 11(2):85-97. PMC: 3518031. DOI: 10.1038/nri2921. View

Choi Y, Kim S, Kang S, Yoon C, Lee H, Youn T . Reconsidering the cut-off diastolic blood pressure for predicting cardiovascular events: a nationwide population-based study from Korea. Eur Heart J. 2018; 40(9):724-731. DOI: 10.1093/eurheartj/ehy801. View

Gelber A, Hochberg M, Mead L, Wang N, Wigley F, Klag M . Body mass index in young men and the risk of subsequent knee and hip osteoarthritis. Am J Med. 2000; 107(6):542-8. DOI: 10.1016/s0002-9343(99)00292-2. View

Yang H, Han K, Kwon H, Park Y, Cho J, Yoon K . Obesity, metabolic health, and mortality in adults: a nationwide population-based study in Korea. Sci Rep. 2016; 6:30329. PMC: 4957204. DOI: 10.1038/srep30329. View

10.

Jiang L, Tian W, Wang Y, Rong J, Bao C, Liu Y . Body mass index and susceptibility to knee osteoarthritis: a systematic review and meta-analysis. Joint Bone Spine. 2011; 79(3):291-7. DOI: 10.1016/j.jbspin.2011.05.015. View

11.

Scotece M, Mobasheri A . Leptin in osteoarthritis: Focus on articular cartilage and chondrocytes. Life Sci. 2015; 140:75-8. DOI: 10.1016/j.lfs.2015.05.025. View

12.

Noh J, Han K, Ko S, Ko K, Park C . Trends in the pervasiveness of type 2 diabetes, impaired fasting glucose and co-morbidities during an 8-year-follow-up of nationwide Korean population. Sci Rep. 2017; 7:46656. PMC: 5397969. DOI: 10.1038/srep46656. View

13.

Kwon H, Han K, Park C . Weight change is significantly associated with risk of thyroid cancer: A nationwide population-based cohort study. Sci Rep. 2019; 9(1):1546. PMC: 6367378. DOI: 10.1038/s41598-018-38203-0. View

14.

Lim U, Ernst T, Buchthal S, Latch M, Albright C, Wilkens L . Asian women have greater abdominal and visceral adiposity than Caucasian women with similar body mass index. Nutr Diabetes. 2013; 1:e6. PMC: 3302135. DOI: 10.1038/nutd.2011.2. View

15.

Lee J, Lee J, Park S, Shin S, Kim K . Cohort Profile: The National Health Insurance Service-National Sample Cohort (NHIS-NSC), South Korea. Int J Epidemiol. 2016; 46(2):e15. DOI: 10.1093/ije/dyv319. View

16.

Choi Y, Choi E, Han K, Jung J, Park J, Lee E . Temporal trends of the prevalence and incidence of atrial fibrillation and stroke among Asian patients with hypertrophic cardiomyopathy: A nationwide population-based study. Int J Cardiol. 2018; 273:130-135. DOI: 10.1016/j.ijcard.2018.08.038. View

17.

Buttgereit F, Burmester G, Bijlsma J . Non-surgical management of knee osteoarthritis: where are we now and where do we need to go?. RMD Open. 2015; 1(1):e000027. PMC: 4613167. DOI: 10.1136/rmdopen-2014-000027. View

18.

. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016; 388(10053):1545-1602. PMC: 5055577. DOI: 10.1016/S0140-6736(16)31678-6. View

19.

Hunter D, Bierma-Zeinstra S . Osteoarthritis. Lancet. 2019; 393(10182):1745-1759. DOI: 10.1016/S0140-6736(19)30417-9. View

20.

Hochberg M, Lethbridge-Cejku M, Scott Jr W, Reichle R, Plato C, Tobin J . The association of body weight, body fatness and body fat distribution with osteoarthritis of the knee: data from the Baltimore Longitudinal Study of Aging. J Rheumatol. 1995; 22(3):488-93. View