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Expression of Trpa1 and Trpv1 Genes in the Hypothalamus and Blood Pressure in Normotensive and Hypertensive Rats. Effect of Losartan and Captopril

Overview
Journal Bull Exp Biol Med
Publisher Springer
Specialty General Medicine
Date 2023 Mar 7
PMID 36881283
Authors
T V Kozyreva
I P Voronova
Affiliations
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Abstract

Analysis of the role of genomic regulation of systolic BP (SBP) in normal and hypertensive rats showed the presence of an inverse relationship between the level of Trpa1 gene expression in the anterior hypothalamus and SBP. Losartan, an antagonist of angiotensin II type 1 receptors, shifts it to the region of lower SBP and greater expression of the Trpa1 gene, which can attest to interaction of the TRPA1 ion channel in the anterior hypothalamus with angiotensin II type 1 receptors. No association was found between the expression of the Trpv1 gene in the hypothalamus and SBP. We have previously shown that activation of the peripheral ion channel TRPA1 in the skin also contributes to SBP decrease in hypertensive animals. Hence, activation of the TRPA1 ion channel both in the brain and at the periphery has similar effects on SBP and leads to its decrease.

References
1.
Sadofsky L, Sreekrishna K, Lin Y, Schinaman R, Gorka K, Mantri Y . Unique Responses are Observed in Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and TRPV1) Co-Expressing Cells. Cells. 2014; 3(2):616-26. PMC: 4092848. DOI: 10.3390/cells3020616. View
2.
Kistner K, Siklosi N, Babes A, Khalil M, Selescu T, Zimmermann K . Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain. Sci Rep. 2016; 6:28621. PMC: 4928060. DOI: 10.1038/srep28621. View
3.
Earley S . TRPA1 channels in the vasculature. Br J Pharmacol. 2012; 167(1):13-22. PMC: 3448909. DOI: 10.1111/j.1476-5381.2012.02018.x. View
4.
Graepel R, Fernandes E, Aubdool A, Andersson D, Bevan S, Brain S . 4-oxo-2-nonenal (4-ONE): evidence of transient receptor potential ankyrin 1-dependent and -independent nociceptive and vasoactive responses in vivo. J Pharmacol Exp Ther. 2011; 337(1):117-24. PMC: 3063740. DOI: 10.1124/jpet.110.172403. View
5.
Phan T, Ton H, Gulyas H, Porszasz R, Toth A, Russo R . TRPV1 expressed throughout the arterial circulation regulates vasoconstriction and blood pressure. J Physiol. 2020; 598(24):5639-5659. PMC: 8565923. DOI: 10.1113/JP279909. View