Literature Overview of the Relation Between Psoriasis and Alzheimer

Overview

Journal Neuropsychiatr Dis Treat

Publisher Dove Medical Press

Specialty Psychiatry

Date 2023 Mar 7

PMID 36879948

Authors

Qian Yang

Jing Wang

Ningyu Mi

Yulin Zou

Affiliations

Soon will be listed here.

Abstract

The most common type of dementia disease is Alzheimer, which placing a heavy burden on the healthcare system all over the world. At the same time, psoriasis is also one of the most common health problems, as a skin disease. Alzheimer's disease (AD) is more often in patients with psoriasis than in the general people. Several evidence has proved the relation between AD and psoriasis through immune-mediated pathophysiologic processes. This review aims to summary the potential relation between AD and psoriasis, and provide suggestions based on the relationship at the same time. Neurologists, dermatologists should pay attention to the relationship between Alzheimer's disease and psoriasis. Dermatology and neurology need referral each other when it is necessary.

Citing Articles

Single-Cell Sequencing and Machine Learning Integration to Identify Candidate Biomarkers in Psoriasis: .

Zhou X, Ning J, Cai R, Liu J, Yang H, Bai Y J Inflamm Res. 2024; 17:11485-11503.

PMID: 39735895 PMC: 11681806. DOI: 10.2147/JIR.S492875.

Single-Cell Sequencing Combined with Transcriptome Sequencing to Explore the Molecular Mechanisms Related to Psoriasis.

E C, Wang R, Meng Z, Zou Y Clin Cosmet Investig Dermatol. 2024; 17:2197-2213.

PMID: 39376789 PMC: 11457778. DOI: 10.2147/CCID.S484034.

References

Pezzolo E, Mutlu U, Vernooij M, Dowlatshahi E, Gisondi P, Girolomoni G . Psoriasis is not associated with cognition, brain imaging markers, and risk for dementia: The Rotterdam Study. J Am Acad Dermatol. 2018; 85(3):671-680. DOI: 10.1016/j.jaad.2018.07.046. View

Di Cesare A, Di Meglio P, Nestle F . The IL-23/Th17 axis in the immunopathogenesis of psoriasis. J Invest Dermatol. 2009; 129(6):1339-50. DOI: 10.1038/jid.2009.59. View

Lee J, Han K, Gee H . The incidence rates and risk factors of Parkinson disease in patients with psoriasis: A nationwide population-based cohort study. J Am Acad Dermatol. 2019; 83(6):1688-1695. DOI: 10.1016/j.jaad.2019.07.012. View

Henes J, Ziupa E, Eisfelder M, Adamczyk A, Knaudt B, Jacobs F . High prevalence of psoriatic arthritis in dermatological patients with psoriasis: a cross-sectional study. Rheumatol Int. 2013; 34(2):227-34. DOI: 10.1007/s00296-013-2876-z. View

De Strooper B, Karran E . The Cellular Phase of Alzheimer's Disease. Cell. 2016; 164(4):603-15. DOI: 10.1016/j.cell.2015.12.056. View

Da Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison R, Kingsmore K . Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease. Nature. 2018; 560(7717):185-191. PMC: 6085146. DOI: 10.1038/s41586-018-0368-8. View

Elder J . Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis. Genes Immun. 2009; 10(3):201-9. PMC: 2683580. DOI: 10.1038/gene.2009.11. View

Neurath M . IL-23: a master regulator in Crohn disease. Nat Med. 2007; 13(1):26-8. DOI: 10.1038/nm0107-26. View

Tan M, Yu J, Jiang T, Zhu X, Guan H, Tan L . IL12/23 p40 inhibition ameliorates Alzheimer's disease-associated neuropathology and spatial memory in SAMP8 mice. J Alzheimers Dis. 2013; 38(3):633-46. DOI: 10.3233/JAD-131148. View

10.

Griffiths C, Barker J . Pathogenesis and clinical features of psoriasis. Lancet. 2007; 370(9583):263-271. DOI: 10.1016/S0140-6736(07)61128-3. View

11.

Decourt B, Lahiri D, Sabbagh M . Targeting Tumor Necrosis Factor Alpha for Alzheimer's Disease. Curr Alzheimer Res. 2016; 14(4):412-425. PMC: 5328927. DOI: 10.2174/1567205013666160930110551. View

12.

Heppner F, Ransohoff R, Becher B . Immune attack: the role of inflammation in Alzheimer disease. Nat Rev Neurosci. 2015; 16(6):358-72. DOI: 10.1038/nrn3880. View

13.

Hodson R . Alzheimer's disease. Nature. 2018; 559(7715):S1. DOI: 10.1038/d41586-018-05717-6. View

14.

Lin C, Lin H, Chiu H . Association Between Psoriasis and Dementia: A Population-Based Case-Control Study. Am J Clin Dermatol. 2019; 20(3):457-463. DOI: 10.1007/s40257-018-00420-8. View

15.

. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016; 388(10053):1545-1602. PMC: 5055577. DOI: 10.1016/S0140-6736(16)31678-6. View

16.

Han Y, Liu T, Lu L . Apolipoprotein E gene polymorphism in psoriasis: a meta-analysis. Arch Med Res. 2012; 44(1):46-53. DOI: 10.1016/j.arcmed.2012.10.009. View

17.

Zhou M, Xu R, Kaelber D, Gurney M . Tumor Necrosis Factor (TNF) blocking agents are associated with lower risk for Alzheimer's disease in patients with rheumatoid arthritis and psoriasis. PLoS One. 2020; 15(3):e0229819. PMC: 7089534. DOI: 10.1371/journal.pone.0229819. View

18.

Lane C, Hardy J, Schott J . Alzheimer's disease. Eur J Neurol. 2017; 25(1):59-70. DOI: 10.1111/ene.13439. View

19.

Griffin W . Neuroinflammatory cytokine signaling and Alzheimer's disease. N Engl J Med. 2013; 368(8):770-1. DOI: 10.1056/NEJMcibr1214546. View

20.

Leisner M, Riis J, Schwartz S, Iversen L, Ostergaard S, Olsen M . Psoriasis and Risk of Mental Disorders in Denmark. JAMA Dermatol. 2019; 155(6):745-747. PMC: 6506870. DOI: 10.1001/jamadermatol.2019.0039. View