Electrochemical Generation and Utilization of Alkoxy Radicals
Overview
Affiliations
This highlight summarises electrochemical approaches for the generation and utilization of alkoxy radicals, predominantly focusing on recent advances (2012-present). The application of electrochemically generated alkoxy radicals in a diverse range of transformations is described, including discussion on reaction mechanisms, scope and limitations, in addition to highlighting future challenges in this burgeoning area of sustainable synthesis.
Electrosynthesis of 1,4-diene derivatives bearing cyclopentene skeleton.
Qiao Y, Fan X, Yuan C, Fang Z, Liu C iScience. 2025; 28(3):111976.
PMID: 40060912 PMC: 11889677. DOI: 10.1016/j.isci.2025.111976.
Wanderley T, Buscemi R, Conboy O, Knight B, Crisenza G J Am Chem Soc. 2024; 146(47):32848-32858.
PMID: 39537202 PMC: 11613428. DOI: 10.1021/jacs.4c13682.
Ju M, Lee S, Marvich H, Lin S J Am Chem Soc. 2024; 146(29):19696-19703.
PMID: 39012345 PMC: 11366976. DOI: 10.1021/jacs.4c07125.
Finis D, Nicewicz D J Am Chem Soc. 2024; .
PMID: 38847590 PMC: 11624318. DOI: 10.1021/jacs.4c05052.
Pulsed electrolysis: enhancing primary benzylic C(sp)-H nucleophilic fluorination.
Atkins A, Chaturvedi A, Tate J, Lennox A Org Chem Front. 2024; 11(3):802-808.
PMID: 38298566 PMC: 10825853. DOI: 10.1039/d3qo01865b.