Inflammation-the Role of TRPA1 Channel

Overview

Journal Front Physiol

Date 2023 Mar 6

PMID 36875034

Authors

Kaifang Yao

Baomin Dou

Yue Zhang

Zhihan Chen

Yanwei Li

Zezhi Fan

Yajing Ma

Simin Du

Jiangshan Wang

Zhifang Xu

YangYang Liu

Xiaowei Lin

Shenjun Wang

Yi Guo

Affiliations

Soon will be listed here.

Abstract

Recently, increasing numbers of studies have demonstrated that transient receptor potential ankyrin 1 (TRPA1) can be used as a potential target for the treatment of inflammatory diseases. TRPA1 is expressed in both neuronal and non-neuronal cells and is involved in diverse physiological activities, such as stabilizing of cell membrane potential, maintaining cellular humoral balance, and regulating intercellular signal transduction. TRPA1 is a multi-modal cell membrane receptor that can sense different stimuli, and generate action potential signals after activation osmotic pressure, temperature, and inflammatory factors. In this study, we introduced the latest research progress on TRPA1 in inflammatory diseases from three different aspects. First, the inflammatory factors released after inflammation interacts with TRPA1 to promote inflammatory response; second, TRPA1 regulates the function of immune cells such as macrophages and T cells, In addition, it has anti-inflammatory and antioxidant effects in some inflammatory diseases. Third, we have summarized the application of antagonists and agonists targeting TRPA1 in the treatment of some inflammatory diseases.

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