Reappraisal of Oxidized HMGB1 As a Mediator and Biomarker

Overview

Journal Future Sci OA

Specialty Biotechnology

Date 2023 Mar 6

PMID 36874369

Authors

Ross Pirnie

Kevin P Gillespie

Clementina Mesaros

Ian A Blair

Affiliations

Soon will be listed here.

Abstract

HMGB1 is a dual-function protein that acts as a chromatin-binding protein and as a danger-associated molecular pattern (DAMP) when released from activated immune cells or injured tissue. In much of the HMGB1 literature, immunomodulatory effects of extracellular HMGB1 are proposed to depend on its oxidation state. However, many of the foundational studies for this model have been retracted or flagged with expressions of concern. The literature on HMGB1 oxidation reveals a diversity of redox proteoforms of HMGB1 that are inconsistent with current models of redox modulation regulating HMGB1 secretion. A recent study of acetaminophen toxicity has identified previously unrecognized HMGB1 oxidized proteoforms. HMGB1 undergoes oxidative modifications that could serve as pathology-specific biomarkers and drug targets.

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