Role of Cancer-associated Mesenchymal Stem Cells in the Tumor Microenvironment: A Review

Overview

Journal Tzu Chi Med J

Specialty General Medicine

Date 2023 Mar 3

PMID 36866340

Authors

Kai-Hung Wang

Dah-Ching Ding

Affiliations

Soon will be listed here.

Abstract

Mesenchymal stem cells (MSCs) were applied to the therapy for degenerative diseases, immune, and inflammation. In tumor microenvironments (TME), different sources of MSCs showed that tumor-promoting and -inhibiting effects were mediated by different signaling pathways. Cancer-associated MSCs (CaMSCs) could be recruited from bone marrow or local tissues and mainly showed tumor-promoting and immunosuppressive effects. The transformed CaMSCs preserve the characteristics of stem cells, but the properties of regulating TME are different. Hence, we specifically focus on CaMSCs and discuss the detailed mechanisms of regulating the development of cancer cells and immune cells. CaMSCs could be a potential therapeutic target in various types of cancer. However, the detailed mechanisms of CaMSCs in the TME are relatively less known and need further study.

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