Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors

Overview

Journal Cancer Res

Specialty Oncology

Date 2023 Mar 2

PMID 36862034

Authors

Sang Jun Yoon

Joseph A Combs

Aimee Falzone

Nicolas Prieto-Farigua

Samantha Caldwell

Hayley D Ackerman

Elsa R Flores

Gina M DeNicola

Affiliations

Soon will be listed here.

Abstract

Significance: Stable isotope 13C1-serine and 13C6-cystine tracing characterizes cysteine metabolism in normal murine tissues and its rewiring in tumors using genetically engineered mouse models of liver, pancreas, and lung cancers.

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