Identification of Consensus Hairpin Loop Structure Among the Negative Sense Subgenomic RNAs of SARS-CoV-2

Overview

Journal Bull Natl Res Cent

Date 2023 Feb 28

PMID 36852284

Authors

Naveen Prakash Bokolia

Ravisekhar Gadepalli

Affiliations

Soon will be listed here.

Abstract

Background: SARS-CoV-2 is the causative agent of worldwide pandemic disease coronavirus disease 19. SARS-CoV-2 bears positive sense RNA genome that has organized and complex pattern of replication/transcription process including the generation of subgenomic RNAs. Transcription regulatory sequences have important role in the pausing of replication/transcription and generation of subgenomic RNAs.

Results: In the present bioinformatics analysis, a consensus secondary structure was identified among negative sense subgenomic RNAs of SARS-CoV-2. This consensus region is present at the adjacent of initiation codon.

Conclusions: This study proposed that consensus structured domain could involve in mediating the long pausing of replication/transcription complex and responsible for subgenomic RNA production.

Supplementary Information: The online version contains supplementary material available at 10.1186/s42269-023-01002-3.

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