Association Between Biological Aging and Lung Cancer Risk: Cohort Study and Mendelian Randomization Analysis

Overview

Journal iScience

Publisher Cell Press

Date 2023 Feb 28

PMID 36852276

Authors

Zhimin Ma

Chen Zhu

Hui Wang

Mengmeng Ji

Yanqian Huang

XiaoXia Wei

Jing Zhang

Yuzhuo Wang

Rong Yin

Juncheng Dai

Lin Xu

Hongxia Ma

Zhibin Hu

Guangfu Jin

Meng Zhu

Hongbing Shen

Affiliations

Soon will be listed here.

Abstract

Chronological age only represents the passage of time, whereas biological age reflects the physiology states and the susceptibility to morbidity and mortality. The association between biological age and lung cancer risk remains controversial. Hence, we conducted a prospective analysis in the UK Biobank study and two-sample Mendelian randomization analysis to investigate this association. Biological aging was evaluated by PhenoAgeAccel, derived from routine clinical biomarkers. Independent of chronological age, PhenoAgeAccel was positively associated with the risk of overall and histological subtypes of lung cancer. There was a joint effect of PhenoAgeAccel and genetics in lung cancer incidence. In Mendelian randomization analysis, the genetically predicted PhenoAgeAccel was associated with the increased risk of overall lung cancer, small cell, and squamous cell carcinoma. Our findings suggest PhenoAgeAccel is an independent risk factor for lung cancer, which could be incorporated with polygenic risk score to identify high-risk individuals for lung cancer.

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