Baculovirus Display of Peptides and Proteins for Medical Applications

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2023 Feb 28

PMID 36851625

Authors

Aaron Pavel Rodriguez-Hernandez

Daniel Martinez-Flores

Adolfo Cruz-Resendiz

Teresa Padilla-Flores

Rodrigo Gonzalez-Flores

Kenia Estrada

Alicia Sampieri

Aldo Roman Camacho-Zarco

Luis Vaca

Affiliations

Soon will be listed here.

Abstract

Baculoviridae is a large family of arthropod-infective viruses. Recombinant baculoviruses have many applications, the best known is as a system for large scale protein production in combination with insect cell cultures. More recently recombinant baculoviruses have been utilized for the display of proteins of interest with applications in medicine. In the present review we analyze the different strategies for the display of proteins and peptides on the surface of recombinant baculoviruses and provide some examples of the different proteins displayed. We analyze briefly the commercially available systems for recombinant baculovirus production and display and discuss the future of this emerging and powerful technology.

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