Study of Cationic Surfactants Raw Materials for COVID-19 Disinfecting Formulations by Potentiometric Surfactant Sensor

Overview

Journal Sensors (Basel)

Publisher MDPI

Specialty Biotechnology

Date 2023 Feb 28

PMID 36850724

Authors

Nikola Sakac

Dubravka Madunic-cacic

Dean Markovic

Marija Jozanovic

Affiliations

Soon will be listed here.

Abstract

The behavior of a new 1,3-dioctadecyl-1-imidazol-3-ium tetraphenylborate (DODI-TPB) surfactant sensor was studied in single and complex mixtures of technical grade QACs-benzalkonium chloride (BAC), -didecyl--dimethylammonium chloride (DDAC), and -dioctyl--dimethylammonium chloride (DOAC) usually used in COVID-19 disinfecting agents formulations. The results obtained with the new DODI-TPB sensor were in good agreement with data measured by a 1,3-dihexadecyl-1-benzo[]imidazol-3-ium-tetraphenylborate (DMI-TPB) surfactant sensor, as well as two-phase titration used as a reference method. The quantitative titrations of a two-component mixture of the cationic homologs (a) DDAC and DOAC; and (b) BAC and DOAC showed that the new DODI-TPB surfactant sensor can clearly distinguish two separate mixture components in a single potentiometric titration curve with two characteristic inflexion points. The consumption of SDS (used as a titrant) in the end-point 1 (EP 1) corresponded to the content of DDAC (or BAC), whereas the consumption in the end-point 2 (EP 2) corresponded to the total content of both cationic surfactants in the mixture. DOAC content in both mixtures can be calculated from the difference of the titrant used to achieve EP1 and EP2. The addition of nonionic surfactants resulted in the signal change decrease from 333.2 mV (1:0; no nonionic surfactant added) to 243.0 mV (1:10, /). The sensor was successfully tested in ten two-component COVID-19 disinfecting formulations.

Citing Articles

Potentiometric Surfactant Sensor with a Pt-Doped Acid-Activated Multi-Walled Carbon Nanotube-Based Ionophore Nanocomposite.

Glumac N, Momcilovic M, Kramberger I, Straus D, Sakac N, Kovac-Andric E Sensors (Basel). 2024; 24(8).

PMID: 38676005 PMC: 11054714. DOI: 10.3390/s24082388.

References

Boyce J, Kelliher S, Vallande N . Skin irritation and dryness associated with two hand-hygiene regimens: soap-and-water hand washing versus hand antisepsis with an alcoholic hand gel. Infect Control Hosp Epidemiol. 2000; 21(7):442-8. DOI: 10.1086/501785. View

Madunic-cacic D, Sak-Bosnar M, Galovic O, Sakac N, Matesic-Puac R . Determination of cationic surfactants in pharmaceutical disinfectants using a new sensitive potentiometric sensor. Talanta. 2008; 76(2):259-64. DOI: 10.1016/j.talanta.2008.02.023. View

Paut A, Prkic A, Mitar I, Guc L, Marcius M, Vrankic M . The New Ion-Selective Electrodes Developed for Ferric Cations Determination, Modified with Synthesized Al and Fe-Based Nanoparticles. Sensors (Basel). 2022; 22(1). PMC: 8749730. DOI: 10.3390/s22010297. View

Sakac N, Madunic-cacic D, Markovic D, Della Ventura B, Velotta R, Pticek Sirocic A . The 1,3-Dioctadecyl-1-imidazol-3-ium Based Potentiometric Surfactant Sensor for Detecting Cationic Surfactants in Commercial Products. Sensors (Basel). 2022; 22(23). PMC: 9739083. DOI: 10.3390/s22239141. View

Simon M, Veit M, Osterrieder K, Gradzielski M . Surfactants - Compounds for inactivation of SARS-CoV-2 and other enveloped viruses. Curr Opin Colloid Interface Sci. 2021; 55:101479. PMC: 8196227. DOI: 10.1016/j.cocis.2021.101479. View

Falk N . Surfactants as Antimicrobials: A Brief Overview of Microbial Interfacial Chemistry and Surfactant Antimicrobial Activity. J Surfactants Deterg. 2020; 22(5):1119-1127. PMC: 7166552. DOI: 10.1002/jsde.12293. View

Dellanno C, Vega Q, Boesenberg D . The antiviral action of common household disinfectants and antiseptics against murine hepatitis virus, a potential surrogate for SARS coronavirus. Am J Infect Control. 2009; 37(8):649-52. PMC: 7132643. DOI: 10.1016/j.ajic.2009.03.012. View

Mohapatra S, Yutao L, Goh S, Ng C, Luhua Y, Tran N . Quaternary ammonium compounds of emerging concern: Classification, occurrence, fate, toxicity and antimicrobial resistance. J Hazard Mater. 2022; 445:130393. PMC: 9663149. DOI: 10.1016/j.jhazmat.2022.130393. View

Kaczerewska O, Martins R, Figueiredo J, Loureiro S, Tedim J . Environmental behaviour and ecotoxicity of cationic surfactants towards marine organisms. J Hazard Mater. 2020; 392:122299. DOI: 10.1016/j.jhazmat.2020.122299. View

10.

Rutala W, Weber D . Disinfection, sterilization, and antisepsis: An overview. Am J Infect Control. 2016; 44(5 Suppl):e1-6. DOI: 10.1016/j.ajic.2015.10.038. View

11.

Vereshchagin A, Frolov N, Egorova K, Seitkalieva M, Ananikov V . Quaternary Ammonium Compounds (QACs) and Ionic Liquids (ILs) as Biocides: From Simple Antiseptics to Tunable Antimicrobials. Int J Mol Sci. 2021; 22(13). PMC: 8268321. DOI: 10.3390/ijms22136793. View

12.

McDonnell G, Russell A . Antiseptics and disinfectants: activity, action, and resistance. Clin Microbiol Rev. 1999; 12(1):147-79. PMC: 88911. DOI: 10.1128/CMR.12.1.147. View

13.

Sakac N, Madunic-cacic D, Karnas M, durin B, Kovac I, Jozanovic M . The Influence of Plasticizers on the Response Characteristics of the Surfactant Sensor for Cationic Surfactant Determination in Disinfectants and Antiseptics. Sensors (Basel). 2021; 21(10). PMC: 8161289. DOI: 10.3390/s21103535. View

14.

Mukherjee S, Vincent C, Jayasekera H, Yekhe A . Antiviral efficacy of personal care formulations against Severe Acute Respiratory Syndrome Coronavirus 2. Infect Dis Health. 2020; 26(1):63-66. PMC: 7498208. DOI: 10.1016/j.idh.2020.09.003. View

15.

Lukasik J, Bradley M, Scott T, Dea M, Koo A, Hsu W . Reduction of poliovirus 1, bacteriophages, Salmonella montevideo, and Escherichia coli O157:H7 on strawberries by physical and disinfectant washes. J Food Prot. 2003; 66(2):188-93. DOI: 10.4315/0362-028x-66.2.188. View

16.

Hora P, Pati S, McNamara P, Arnold W . Increased Use of Quaternary Ammonium Compounds during the SARS-CoV-2 Pandemic and Beyond: Consideration of Environmental Implications. Environ Sci Technol Lett. 2023; 7(9):622-631. DOI: 10.1021/acs.estlett.0c00437. View

17.

Tsujimura K, Murase H, Bannai H, Nemoto M, Yamanaka T, Kondo T . Efficacy of five commercial disinfectants and one anionic surfactant against equine herpesvirus type 1. J Vet Med Sci. 2015; 77(11):1545-8. PMC: 4667681. DOI: 10.1292/jvms.15-0030. View

18.

Jantafong T, Ruenphet S, Punyadarsaniya D, Takehara K . The study of effect of didecyl dimethyl ammonium bromide on bacterial and viral decontamination for biosecurity in the animal farm. Vet World. 2018; 11(5):706-711. PMC: 5993774. DOI: 10.14202/vetworld.2018.706-711. View

19.

Romanowski E, Yates K, Shanks R, Kowalski R . Benzalkonium Chloride Demonstrates Concentration-Dependent Antiviral Activity Against Adenovirus . J Ocul Pharmacol Ther. 2019; 35(5):311-314. PMC: 6588108. DOI: 10.1089/jop.2018.0145. View

20.

Goh C, Ming L, Wong L . Dermatologic reactions to disinfectant use during the COVID-19 pandemic. Clin Dermatol. 2021; 39(2):314-322. PMC: 7529601. DOI: 10.1016/j.clindermatol.2020.09.005. View