Analysis of Antimicrobial Resistance and Genetic Correlations of in Dairy Cow Mastitis

Overview

Journal J Vet Res

Publisher Sciendo

Specialty Veterinary Medicine

Date 2023 Feb 27

PMID 36846038

Authors

Ke Li

Mingyuan Hou

Lin Zhang

Mengyue Tian

Ming Yang

Li Jia

Yanyan Liang

Dongmin Zou

Ruonan Liu

Yuzhong Ma

Affiliations

Soon will be listed here.

Abstract

Introduction: is a widespread environmental pathogen frequently causing dairy cow mastitis. This bacterium is particularly capable of acquiring antimicrobial resistance, which can have severe impacts on animal food safety and human health. The objective of the study was to investigate antimicrobial resistance and genetic correlations of from dairy cow mastitis cases in northern China.

Material And Methods: Forty strains of from 196 mastitis milk samples were collected, susceptibility to 13 common antibiotics and the prevalence of resistance genes were tested in these strains, and the genetic characteristics were identified by multilocus sequence typing.

Results: The results showed that most isolates were multidrug resistant (MDR) (75%), and the resistance rates to cefazolin, trimethoprim-sulfamethoxazole and ampicillin were 77.5%, 55.0%, and 52.5%, respectively. The representative genes of the isolates were (62.5%) and (B) (60.0%). Multilocus sequence typing showed 19 different sequence types (STs) and 5 clonal complexes (CCs) in the 40 isolates, mainly represented by ST10 and CC10. The strains of the same ST or CC showed a high level of genetic relatedness, but the characteristics of their antimicrobial resistance were markedly different.

Conclusion: Most isolates in the study were MDR strains. Some strains of the same ST or CC showed diverse resistance characteristics to common antimicrobials. Therefore, from dairy cow mastitis in northern China should be investigated to elucidate its antimicrobial resistance and genotypes.

Citing Articles

Prevalent and Drug-Resistant Phenotypes and Genotypes of Isolated from Healthy Cow's Milk of Large-Scale Dairy Farms in China.

Gao J, Wu Y, Ma X, Xu X, Tuerdi A, Shao W Int J Mol Sci. 2025; 26(2).

PMID: 39859170 PMC: 11764516. DOI: 10.3390/ijms26020454.

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