Tobacco Nicotine Promotes TRAIL Resistance in Lung Cancer Through SNHG5

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2023 Feb 27

PMID 36845946

Authors

Xin Xiao

Juan Xu

Xiaoan Sheng

Chao Wang

Juanjuan Dong

Xianfeng Shi

Affiliations

Soon will be listed here.

Abstract

Tobacco nicotine use is carcinogenic and a well-known risk factor for lung cancer. However, whether tobacco nicotine can induce drug resistance in lung cancer is not clear. The objective of the present study was to identify the TNF-related apoptosis-inducing ligand (TRAIL) resistance of long noncoding RNAs (lncRNAs) that are differentially expressed in smokers and nonsmokers with lung cancer. The results suggested that the nicotine upregulated small nucleolar RNA host gene 5 (SNHG5) and markedly decreased the levels of cleaved caspase-3. The present study found that cytoplasm lncRNA SNHG5 overexpression was associated with TRAIL resistance in lung cancer and that SNHG5 can interact with X-linked inhibitor of apoptosis protein to promote TRAIL resistance. Therefore, nicotine promoted TRAIL resistance in lung cancer through SNHG5/X-linked inhibitor of apoptosis protein.

Citing Articles

Lnc-SNHG5 Promoted Hepatocellular Carcinoma Progression Through the RPS3-NFκB Pathway.

Hao J, Liu Y, Guo F, Fu G, Ning J, Ruan X Int J Gen Med. 2023; 16:5651-5664.

PMID: 38059157 PMC: 10697148. DOI: 10.2147/IJGM.S442937.

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