Late Neurological Consequences of SARS-CoV-2 Infection: New Challenges for the Neurologist

Overview

Journal Front Neurosci

Date 2023 Feb 27

PMID 36845421

Authors

Agnieszka Korchut

Konrad Rejdak

Affiliations

Soon will be listed here.

Abstract

Objective: In this study, a systematic review of the literature was performed to study the frequency of neurological symptoms and diseases in adult patients with COVID-19 that may be late consequences of SARS-CoV-2 infection.

Methods: Relevant studies were identified through electronic explorations of Scopus, PubMed, and Google Scholar. We followed PRISMA guidelines. Data were collected from studies where the diagnosis of COVID-19 was confirmed and its late neurological consequences occurred at least 4 weeks after initial SARS-CoV-2 infection. Review articles were excluded from the study. Neurological manifestations were stratified based on frequency (above 5, 10, and 20%), where the number of studies and sample size were significant.

Results: A total of 497 articles were identified for eligible content. This article provides relevant information from 45 studies involving 9,746 patients. Fatigue, cognitive problems, and smell and taste dysfunctions were the most frequently reported long-term neurological symptoms in patients with COVID-19. Other common neurological issues were paresthesia, headache, and dizziness.

Conclusion: On a global scale of patients affected with COVID-19, prolonged neurological problems have become increasingly recognized and concerning. Our review might be an additional source of knowledge about potential long-term neurological impacts.

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References

Aasfara J, Hajjij A, Bensouda H, Ouhabi H, Benariba F . A unique association of bifacial weakness, paresthesia and vestibulocochlear neuritis as post-COVID-19 manifestation in pregnant women: a case report. Pan Afr Med J. 2021; 38:30. PMC: 7955605. DOI: 10.11604/pamj.2021.38.30.27646. View

Park S, Majoka H, Sheikh A, Ali I . A presumed case of new-onset focal seizures as a delayed complication of COVID-19 infection. Epilepsy Behav Rep. 2021; 16:100447. PMC: 8011035. DOI: 10.1016/j.ebr.2021.100447. View

Orru G, Bertelloni D, Diolaiuti F, Mucci F, Di Giuseppe M, Biella M . Long-COVID Syndrome? A Study on the Persistence of Neurological, Psychological and Physiological Symptoms. Healthcare (Basel). 2021; 9(5). PMC: 8152255. DOI: 10.3390/healthcare9050575. View

Huang C, Huang L, Wang Y, Li X, Ren L, Gu X . 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet. 2021; 397(10270):220-232. PMC: 7833295. DOI: 10.1016/S0140-6736(20)32656-8. View

McFarland A, Yousuf M, Shiers S, Price T . Neurobiology of SARS-CoV-2 interactions with the peripheral nervous system: implications for COVID-19 and pain. Pain Rep. 2021; 6(1):e885. PMC: 7803673. DOI: 10.1097/PR9.0000000000000885. View

Garrigues E, Janvier P, Kherabi Y, Le Bot A, Hamon A, Gouze H . Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19. J Infect. 2020; 81(6):e4-e6. PMC: 7445491. DOI: 10.1016/j.jinf.2020.08.029. View

Boesl F, Audebert H, Endres M, Pruss H, Franke C . A Neurological Outpatient Clinic for Patients With Post-COVID-19 Syndrome - A Report on the Clinical Presentations of the First 100 Patients. Front Neurol. 2021; 12:738405. PMC: 8481602. DOI: 10.3389/fneur.2021.738405. View

Sasannejad C, Wesley Ely E, Lahiri S . Long-term cognitive impairment after acute respiratory distress syndrome: a review of clinical impact and pathophysiological mechanisms. Crit Care. 2019; 23(1):352. PMC: 6852966. DOI: 10.1186/s13054-019-2626-z. View

Zhang X, Wang F, Shen Y, Zhang X, Cen Y, Wang B . Symptoms and Health Outcomes Among Survivors of COVID-19 Infection 1 Year After Discharge From Hospitals in Wuhan, China. JAMA Netw Open. 2021; 4(9):e2127403. PMC: 8482055. DOI: 10.1001/jamanetworkopen.2021.27403. View

10.

Mendelson M, Nel J, Blumberg L, Madhi S, Dryden M, Stevens W . Long-COVID: An evolving problem with an extensive impact. S Afr Med J. 2021; 111(1):10-12. DOI: 10.7196/SAMJ.2020.v111i11.15433. View

11.

Zhu Y, Cao M, Zheng P, Shen W . Residual olfactory dysfunction in coronavirus disease 2019 patients after long term recovery. J Clin Neurosci. 2021; 93:31-35. PMC: 8315939. DOI: 10.1016/j.jocn.2021.07.050. View

12.

Nakamura I, Itoi T, Inoue T . Case report of restless anal syndrome as restless legs syndrome variant after COVID-19. BMC Infect Dis. 2021; 21(1):993. PMC: 8460186. DOI: 10.1186/s12879-021-06683-7. View

13.

Somani S, Pati S, Gaston T, Chitlangia A, Agnihotri S . De Novo Status Epilepticus in patients with COVID-19. Ann Clin Transl Neurol. 2020; 7(7):1240-1244. PMC: 7273010. DOI: 10.1002/acn3.51071. View

14.

Lippi G, Mattiuzzi C, Bovo C, Henry B . Headache is an important symptom in patients with coronavirus disease 2019 (COVID-19). Diagnosis (Berl). 2020; 7(4):409-411. DOI: 10.1515/dx-2020-0048. View

15.

Siow I, Lee K, Zhang J, Saffari S, Ng A . Encephalitis as a neurological complication of COVID-19: A systematic review and meta-analysis of incidence, outcomes, and predictors. Eur J Neurol. 2021; 28(10):3491-3502. PMC: 8239820. DOI: 10.1111/ene.14913. View

16.

Bozzali M, Grassini A, Morana G, Zotta M, Cabras S, Romagnolo A . Focal seizures with impaired awareness as long-term neurological complication of COVID-19: a case report. Neurol Sci. 2021; 42(7):2619-2623. PMC: 8051830. DOI: 10.1007/s10072-021-05233-y. View

17.

Townsend L, Dyer A, Jones K, Dunne J, Mooney A, Gaffney F . Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection. PLoS One. 2020; 15(11):e0240784. PMC: 7652254. DOI: 10.1371/journal.pone.0240784. View

18.

Hosseiny M, Kooraki S, Gholamrezanezhad A, Reddy S, Myers L . Radiology Perspective of Coronavirus Disease 2019 (COVID-19): Lessons From Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome. AJR Am J Roentgenol. 2020; 214(5):1078-1082. DOI: 10.2214/AJR.20.22969. View

19.

Vanichkachorn G, Newcomb R, Cowl C, Murad M, Breeher L, Miller S . Post-COVID-19 Syndrome (Long Haul Syndrome): Description of a Multidisciplinary Clinic at Mayo Clinic and Characteristics of the Initial Patient Cohort. Mayo Clin Proc. 2021; 96(7):1782-1791. PMC: 8112396. DOI: 10.1016/j.mayocp.2021.04.024. View

20.

Halpin S, McIvor C, Whyatt G, Adams A, Harvey O, McLean L . Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluation. J Med Virol. 2020; 93(2):1013-1022. DOI: 10.1002/jmv.26368. View