Role of LncRNAs in the Pathogenic Mechanism of Human Decreased Ovarian Reserve

Overview

Journal Front Genet

Date 2023 Feb 27

PMID 36845376

Authors

Zhexi Lv

Zekai Lv

Linjiang Song

Qinxiu Zhang

Shaomi Zhu

Affiliations

Soon will be listed here.

Abstract

Decreased ovarian reserve (DOR) is defined as a decrease in the quality and quantity of oocytes, which reduces ovarian endocrine function and female fertility. The impaired follicular development and accelerated follicle atresia lead to a decrease in the number of follicles, while the decline of oocyte quality is related to the disorder of DNA damage-repair, oxidative stress, and the dysfunction of mitochondria. Although the mechanism of DOR is still unclear, recent studies have found that long non-coding RNA (lncRNA) as a group of functional RNA molecules participate in the regulation of ovarian function, especially in the differentiation, proliferation and apoptosis of granulosa cells in the ovary. LncRNAs participate in the occurrence of DOR by affecting follicular development and atresia, the synthesis and secretion of ovarian hormones. This review summarizes current research on lncRNAs associated with DOR and reveals the potential underlying mechanisms. The present study suggests that lncRNAs could be considered as prognostic markers and treatment targets for DOR.

Citing Articles

FOXL2 interaction with different binding partners regulates the dynamics of ovarian development.

Migale R, Neumann M, Mitter R, Rafiee M, Wood S, Olsen J Sci Adv. 2024; 10(12):eadl0788.

PMID: 38517962 PMC: 10959415. DOI: 10.1126/sciadv.adl0788.

Bushen Huoxue formula for the treatment of diminished ovarian reserve: A combined metabolomics and integrated network pharmacology analysis.

Zeng P, Zhou H, Guo P, Han N, Zhang X, Yin Z Heliyon. 2023; 9(9):e20104.

PMID: 37809906 PMC: 10559866. DOI: 10.1016/j.heliyon.2023.e20104.

References

Elizur S, Dratviman-Storobinsky O, Derech-Haim S, Lebovitz O, Dor J, Orvieto R . FMR6 may play a role in the pathogenesis of fragile X-associated premature ovarian insufficiency. Gynecol Endocrinol. 2015; 32(4):334-7. DOI: 10.3109/09513590.2015.1116508. View

Elizur S, Friedman Gohas M, Dratviman-Storobinsky O, Cohen Y . Pathophysiology Mechanisms in Fragile-X Primary Ovarian Insufficiency. Methods Mol Biol. 2019; 1942:165-171. DOI: 10.1007/978-1-4939-9080-1_14. View

Dixit H, Rao L, Padmalatha V, Kanakavalli M, Deenadayal M, Gupta N . Missense mutations in the BMP15 gene are associated with ovarian failure. Hum Genet. 2006; 119(4):408-15. DOI: 10.1007/s00439-006-0150-0. View

Li D, Wang X, Dang Y, Zhang X, Zhao S, Lu G . lncRNA is involved in premature ovarian insufficiency by regulating p27 translation in GCs via competitive binding to PTBP1. Mol Ther Nucleic Acids. 2020; 23:132-141. PMC: 7733005. DOI: 10.1016/j.omtn.2020.10.041. View

Aldonza M, Hong J, Lee S . Paclitaxel-resistant cancer cell-derived secretomes elicit ABCB1-associated docetaxel cross-resistance and escape from apoptosis through FOXO3a-driven glycolytic regulation. Exp Mol Med. 2017; 49(1):e286. PMC: 5291837. DOI: 10.1038/emm.2016.131. View

Liu T, Wang S, Zhang L, Guo L, Yu Z, Chen C . Growth hormone treatment of premature ovarian failure in a mouse model via stimulation of the Notch-1 signaling pathway. Exp Ther Med. 2016; 12(1):215-221. PMC: 4906989. DOI: 10.3892/etm.2016.3326. View

Zhou X, Zhang W, Jin M, Chen J, Xu W, Kong X . lncRNA MIAT functions as a competing endogenous RNA to upregulate DAPK2 by sponging miR-22-3p in diabetic cardiomyopathy. Cell Death Dis. 2017; 8(7):e2929. PMC: 5550866. DOI: 10.1038/cddis.2017.321. View

Xiong Y, Liu T, Wang S, Chi H, Chen C, Zheng J . Cyclophosphamide promotes the proliferation inhibition of mouse ovarian granulosa cells and premature ovarian failure by activating the lncRNA-Meg3-p53-p66Shc pathway. Gene. 2016; 596:1-8. DOI: 10.1016/j.gene.2016.10.011. View

Gao Y, Zhu T, Chen J, Liu L, Ouyang R . Knockdown of collagen α-1(III) inhibits glioma cell proliferation and migration and is regulated by miR128-3p. Oncol Lett. 2018; 16(2):1917-1923. PMC: 6036335. DOI: 10.3892/ol.2018.8830. View

10.

Li H, Yang J, Jiang R, Wei X, Song C, Huang Y . Long Non-coding RNA Profiling Reveals an Abundant MDNCR that Promotes Differentiation of Myoblasts by Sponging miR-133a. Mol Ther Nucleic Acids. 2018; 12:610-625. PMC: 6078111. DOI: 10.1016/j.omtn.2018.07.003. View

11.

Gao Q, Sun L, Xiang F, Gao L, Jia Y, Zhang J . Crybb2 deficiency impairs fertility in female mice. Biochem Biophys Res Commun. 2014; 453(1):37-42. DOI: 10.1016/j.bbrc.2014.09.049. View

12.

Wang X, Zhang X, Dang Y, Li D, Lu G, Chan W . Long noncoding RNA HCP5 participates in premature ovarian insufficiency by transcriptionally regulating MSH5 and DNA damage repair via YB1. Nucleic Acids Res. 2020; 48(8):4480-4491. PMC: 7192606. DOI: 10.1093/nar/gkaa127. View

13.

Liu G, Liu S, Xing G, Wang F . lncRNA PVT1/MicroRNA-17-5p/PTEN Axis Regulates Secretion of E2 and P4, Proliferation, and Apoptosis of Ovarian Granulosa Cells in PCOS. Mol Ther Nucleic Acids. 2020; 20:205-216. PMC: 7078124. DOI: 10.1016/j.omtn.2020.02.007. View

14.

Idogawa M, Ohashi T, Sasaki Y, Nakase H, Tokino T . Long non-coding RNA NEAT1 is a transcriptional target of p53 and modulates p53-induced transactivation and tumor-suppressor function. Int J Cancer. 2017; 140(12):2785-2791. DOI: 10.1002/ijc.30689. View

15.

Dykes I, Emanueli C . Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA. Genomics Proteomics Bioinformatics. 2017; 15(3):177-186. PMC: 5487525. DOI: 10.1016/j.gpb.2016.12.005. View

16.

Levine A, Tomasini R, McKeon F, Mak T, Melino G . The p53 family: guardians of maternal reproduction. Nat Rev Mol Cell Biol. 2011; 12(4):259-65. DOI: 10.1038/nrm3086. View

17.

Yao X, Gao X, Bao Y, El-Samahy M, Yang J, Wang Z . lncRNA promotes apoptosis of granulosa cells by targeting the miR-543-3p/DCN/TGF-β signaling pathway in Hu sheep. Mol Ther Nucleic Acids. 2021; 24:223-240. PMC: 7973142. DOI: 10.1016/j.omtn.2021.02.030. View

18.

Shen M, Jiang Y, Guan Z, Cao Y, Li L, Liu H . Protective mechanism of FSH against oxidative damage in mouse ovarian granulosa cells by repressing autophagy. Autophagy. 2017; 13(8):1364-1385. PMC: 5584866. DOI: 10.1080/15548627.2017.1327941. View

19.

Li M, Peng J, Zeng Z . Overexpression of long non-coding RNA nuclear enriched abundant transcript 1 inhibits the expression of p53 and improves premature ovarian failure. Exp Ther Med. 2020; 20(5):69. PMC: 7490781. DOI: 10.3892/etm.2020.9197. View

20.

Mandon-Pepin B, Touraine P, Kuttenn F, Derbois C, Rouxel A, Matsuda F . Genetic investigation of four meiotic genes in women with premature ovarian failure. Eur J Endocrinol. 2008; 158(1):107-15. DOI: 10.1530/EJE-07-0400. View