Targeting β-glucans, Vital Components of the Cell Wall

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2023 Feb 27

PMID 36845149

Authors

Mengyan Wang

Zhongdong Zhang

Xiaotian Dong

Biao Zhu

Affiliations

Soon will be listed here.

Abstract

β-glucan is the most abundant polysaccharide in the cell wall of , which has attracted extensive attention because of its unique immunobiological characteristics. β-glucan binds to various cell surface receptors, which produces an inflammatory response and accounts for its immune effects. A deeper comprehension of the processes by β-glucan recognizes its receptors, activates related signaling pathways, and regulates immunity as required. Such understanding will provide a basis for developing new therapies against . Herein, we briefly review the structural composition of β-glucans as a vital component of the cell wall, the host immunity mediated by β-glucans after their recognition, and discuss opportunities for the development of new strategies to combat .

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