Istegrate (DIN) Theory Enabling Precision Engineering of Proteins

Overview

Journal ACS Cent Sci

Specialty Chemistry

Date 2023 Feb 27

PMID 36844488

Authors

Preeti Chauhan

Ragendu V

Mohan Kumar

Rajib Molla

Unnikrishnan V B

Vishal Rai

Affiliations

Soon will be listed here.

Abstract

The chemical toolbox for the selective modification of proteins has witnessed immense interest in the past few years. The rapid growth of biologics and the need for precision therapeutics have fuelled this growth further. However, the broad spectrum of selectivity parameters creates a roadblock to the field's growth. Additionally, bond formation and dissociation are significantly redefined during the translation from small molecules to proteins. Understanding these principles and developing theories to deconvolute the multidimensional attributes could accelerate the area. This outlook presents a istegrate (DIN) theory for systematically isintegrating the selectivity challenges through reversible chemical reactions. An irreversible step concludes the reaction sequence to render an tegrated solution for precise protein bioconjugation. In this perspective, we highlight the key advancements, unsolved challenges, and potential opportunities.

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