HLA and Red Blood Cell Antigen Genotyping in SARS-CoV-2 Convalescent Plasma Donors

Overview

Journal Future Virol

Specialty Microbiology

Date 2023 Feb 27

PMID 36844192

Authors

William Lemieux

Josee Perreault

Gabriel Andre Leiva-Torres

Nadia Baillargeon

Jessica Constanzo Yanez

Marie-Claire Chevrier

Lucie Richard

Antoine Lewin

Patrick Trepanier

Affiliations

Soon will be listed here.

Abstract

More data is required regarding the association between HLA allele and red blood cell (RBC) antigen expression in regard to SARS-CoV-2 infection and COVID-19 susceptibility. ABO, RhD, 37 other RBC antigens and HLA-A, B, C, DRB1, DQB1 and DPB1 were determined using high throughput platforms in 90 Caucasian convalescent plasma donors. The AB group was significantly increased (1.5×, p = 0.018) and some HLA alleles were found to be significantly overrepresented (HLA-B*44:02, C*05:01, DPB1*04:01, DRB1*04:01 and DRB1*07:01) or underrepresented (A*01:01, B51:01 and DPB1*04:02) in convalescent individuals compared with the local bone marrow registry population. Our study of infection-susceptible but non-hospitalized Caucasian COVID-19 patients contributes to the global understanding of host genetic factors associated with SARS-CoV-2 infection and severity.

References

Lighter J, Phillips M, Hochman S, Sterling S, Johnson D, Francois F . Obesity in Patients Younger Than 60 Years Is a Risk Factor for COVID-19 Hospital Admission. Clin Infect Dis. 2020; 71(15):896-897. PMC: 7184372. DOI: 10.1093/cid/ciaa415. View

Nguyen A, David J, Maden S, Wood M, Weeder B, Nellore A . Human Leukocyte Antigen Susceptibility Map for Severe Acute Respiratory Syndrome Coronavirus 2. J Virol. 2020; 94(13). PMC: 7307149. DOI: 10.1128/JVI.00510-20. View

Warren R, Birol I . HLA predictions from the bronchoalveolar lavage fluid and blood samples of eight COVID-19 patients at the pandemic onset. Bioinformatics. 2020; 36(21):5271-5273. PMC: 7540287. DOI: 10.1093/bioinformatics/btaa756. View

Guo W, Li M, Dong Y, Zhou H, Zhang Z, Tian C . Diabetes is a risk factor for the progression and prognosis of COVID-19. Diabetes Metab Res Rev. 2020; 36(7):e3319. PMC: 7228407. DOI: 10.1002/dmrr.3319. View

Gragert L, Madbouly A, Freeman J, Maiers M . Six-locus high resolution HLA haplotype frequencies derived from mixed-resolution DNA typing for the entire US donor registry. Hum Immunol. 2013; 74(10):1313-20. DOI: 10.1016/j.humimm.2013.06.025. View

Pisanti S, Deelen J, Gallina A, Caputo M, Citro M, Abate M . Correlation of the two most frequent HLA haplotypes in the Italian population to the differential regional incidence of Covid-19. J Transl Med. 2020; 18(1):352. PMC: 7491019. DOI: 10.1186/s12967-020-02515-5. View

Hu B, Huang S, Yin L . The cytokine storm and COVID-19. J Med Virol. 2020; 93(1):250-256. PMC: 7361342. DOI: 10.1002/jmv.26232. View

Tournamille C, Colin Y, Cartron J, Le Van Kim C . Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals. Nat Genet. 1995; 10(2):224-8. DOI: 10.1038/ng0695-224. View

Debnath M, Banerjee M, Berk M . Genetic gateways to COVID-19 infection: Implications for risk, severity, and outcomes. FASEB J. 2020; 34(7):8787-8795. PMC: 7300732. DOI: 10.1096/fj.202001115R. View

10.

Wu S, Arthur C, Wang J, Verkerke H, Josephson C, Kalman D . The SARS-CoV-2 receptor-binding domain preferentially recognizes blood group A. Blood Adv. 2021; 5(5):1305-1309. PMC: 7929867. DOI: 10.1182/bloodadvances.2020003259. View

11.

Tavasolian F, Rashidi M, Hatam G, Jeddi M, Zavaran Hosseini A, Mosawi S . HLA, Immune Response, and Susceptibility to COVID-19. Front Immunol. 2021; 11:601886. PMC: 7820778. DOI: 10.3389/fimmu.2020.601886. View

12.

Barnkob M, Pottegard A, Stovring H, Haunstrup T, Homburg K, Larsen R . Reduced prevalence of SARS-CoV-2 infection in ABO blood group O. Blood Adv. 2020; 4(20):4990-4993. PMC: 7594382. DOI: 10.1182/bloodadvances.2020002657. View

13.

Novelli A, Andreani M, Biancolella M, Liberatoscioli L, Passarelli C, Colona V . HLA allele frequencies and susceptibility to COVID-19 in a group of 99 Italian patients. HLA. 2020; 96(5):610-614. PMC: 7461491. DOI: 10.1111/tan.14047. View

14.

Tomita Y, Ikeda T, Sato R, Sakagami T . Association between HLA gene polymorphisms and mortality of COVID-19: An in silico analysis. Immun Inflamm Dis. 2020; 8(4):684-694. PMC: 7654404. DOI: 10.1002/iid3.358. View

15.

Callard F, Perego E . How and why patients made Long Covid. Soc Sci Med. 2020; 268:113426. PMC: 7539940. DOI: 10.1016/j.socscimed.2020.113426. View

16.

Saulle I, Vicentini C, Clerici M, Biasin M . Antigen presentation in SARS-CoV-2 infection: the role of class I HLA and ERAP polymorphisms. Hum Immunol. 2021; 82(8):551-560. PMC: 8108382. DOI: 10.1016/j.humimm.2021.05.003. View

17.

Kangelaris K, Sapru A, Calfee C, Liu K, Pawlikowska L, Witte J . The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury. Chest. 2011; 141(5):1160-1169. PMC: 3342784. DOI: 10.1378/chest.11-1766. View

18.

Shkurnikov M, Nersisyan S, Jankevic T, Galatenko A, Gordeev I, Vechorko V . Association of HLA Class I Genotypes With Severity of Coronavirus Disease-19. Front Immunol. 2021; 12:641900. PMC: 7959787. DOI: 10.3389/fimmu.2021.641900. View

19.

Yamamoto N, Ariumi Y, Nishida N, Yamamoto R, Bauer G, Gojobori T . SARS-CoV-2 infections and COVID-19 mortalities strongly correlate with ACE1 I/D genotype. Gene. 2020; 758:144944. PMC: 7833925. DOI: 10.1016/j.gene.2020.144944. View

20.

Correale P, Mutti L, Pentimalli F, Baglio G, Saladino R, Sileri P . HLA-B*44 and C*01 Prevalence Correlates with Covid19 Spreading across Italy. Int J Mol Sci. 2020; 21(15). PMC: 7432860. DOI: 10.3390/ijms21155205. View